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Arhgap26 Rho GTPase activating protein 26 [ Mus musculus (house mouse) ]

Gene ID: 71302, updated on 28-Oct-2024

Summary

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Official Symbol
Arhgap26provided by MGI
Official Full Name
Rho GTPase activating protein 26provided by MGI
Primary source
MGI:MGI:1918552
See related
Ensembl:ENSMUSG00000036452 AllianceGenome:MGI:1918552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0621; 1810044B20Rik; 2610010G17Rik; 4933432P15Rik
Summary
Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Is expressed in amygdala; diencephalon lateral wall mantle layer; hypothalamus mantle layer; olfactory epithelium; and telencephalon mantle layer. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in cerebellum adult (RPKM 9.3), cortex adult (RPKM 5.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap26 in Genome Data Viewer
Location:
18 B3; 18 20.51 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38734531..39509338)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38601617..39376285)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44374 Neighboring gene STARR-seq mESC enhancer starr_44375 Neighboring gene STARR-seq mESC enhancer starr_44376 Neighboring gene STARR-seq mESC enhancer starr_44377 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene predicted gene, 19774 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44384 Neighboring gene STARR-seq mESC enhancer starr_44387 Neighboring gene fibroblast growth factor 1 Neighboring gene STARR-seq mESC enhancer starr_44390 Neighboring gene predicted gene 5820 Neighboring gene STARR-positive B cell enhancer ABC_E10987 Neighboring gene STARR-positive B cell enhancer ABC_E4246 Neighboring gene predicted gene, 52330 Neighboring gene STARR-seq mESC enhancer starr_44392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:39242828-39243011 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:39243680-39243789 Neighboring gene STARR-seq mESC enhancer starr_44393 Neighboring gene STARR-seq mESC enhancer starr_44394 Neighboring gene STARR-seq mESC enhancer starr_44395 Neighboring gene STARR-seq mESC enhancer starr_44397 Neighboring gene STARR-seq mESC enhancer starr_44398 Neighboring gene STARR-seq mESC enhancer starr_44400 Neighboring gene STARR-seq mESC enhancer starr_44401 Neighboring gene predicted gene 15337 Neighboring gene predicted gene, 57770 Neighboring gene STARR-positive B cell enhancer ABC_E10988 Neighboring gene STARR-positive B cell enhancer ABC_E10989 Neighboring gene nuclear receptor subfamily 3, group C, member 1 Neighboring gene predicted gene, 54019

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GRAF1 promotes ferlin-dependent myoblast fusion. Lenhart KC, et al. Dev Biol, 2014 Sep 15. PMID 25019370, Free PMC Article
  2. ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility. Zhu Q, et al. Autophagy, 2024 Aug. PMID 38855880,
  3. GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice. Lenhart KC, et al. Skelet Muscle, 2015. PMID 26301073, Free PMC Article
  4. Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss. Lee S, et al. J Neurosci, 2019 Mar 6. PMID 30626696, Free PMC Article
  5. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Zhu Q, et al. Nat Commun, 2023 Dec 11. PMID 38081847, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
    Title: ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
  2. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
    Title: GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
  3. Study shows that brain Pyk2 interacts with the RhoGAP protein Graf1 to alter dendritic spine stability via RhoA GTPase. Amyloid-beta oligomer-induced dendritic spine loss requires the Pyk2/Graf1 pathway.
    Title: Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.
  4. GRAF1 and 2 facilitate myoblast fusion, at least in part, by promoting vesicle-mediated translocation of fusogenic ferlin proteins to the plasma membrane.
    Title: GRAF1 promotes ferlin-dependent myoblast fusion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 26
Names
rho-type GTPase-activating protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361073.1 → NP_001348002.1  rho GTPase-activating protein 26 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorterC, compared to isoform 1.
    Source sequence(s)
    AC110730, AC129603, AC132450
    Consensus CDS
    CCDS89227.1
    UniProtKB/TrEMBL
    B9EJ96, F6T836
    Related
    ENSMUSP00000121197.3, ENSMUST00000137497.9
    Conserved Domains (4) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:667 → 722
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  2. NM_001374831.1 → NP_001361760.1  rho GTPase-activating protein 26 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110730, AC129603, AC132450
    Consensus CDS
    CCDS89226.1
    UniProtKB/TrEMBL
    B9EJ96, E9QAQ3
    Related
    ENSMUSP00000122371.2, ENSMUST00000155576.8
    Conserved Domains (4) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:704 → 759
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  3. NM_175164.4 → NP_780373.3  rho GTPase-activating protein 26 isoform 1

    See identical proteins and their annotated locations for NP_780373.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC007995, AK011368, AK129176, AK152368, BM935209
    Consensus CDS
    CCDS29205.1
    UniProtKB/Swiss-Prot
    E9QLL3, Q6ZQ82
    UniProtKB/TrEMBL
    B9EJ96
    Related
    ENSMUSP00000095200.3, ENSMUST00000097593.9
    Conserved Domains (5) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:759 → 814
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 364
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    38734531..39509338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161285.1 → XP_036017178.1  rho GTPase-activating protein 26 isoform X4

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd12064
    Location:676 → 731
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:373 → 572
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:276 → 380
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:61 → 234
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_030250607.2 → XP_030106467.1  rho GTPase-activating protein 26 isoform X2

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd12064
    Location:757 → 812
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:362 → 561
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:265 → 369
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:50 → 223
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_036161286.1 → XP_036017179.1  rho GTPase-activating protein 26 isoform X5

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd12064
    Location:665 → 720
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:362 → 561
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:265 → 369
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:50 → 223
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_017317984.2 → XP_017173473.2  rho GTPase-activating protein 26 isoform X2

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd12064
    Location:757 → 812
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:362 → 561
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:265 → 369
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:50 → 223
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_036161284.1 → XP_036017177.1  rho GTPase-activating protein 26 isoform X1

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd12064
    Location:768 → 823
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:373 → 572
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:276 → 380
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:61 → 234
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_006526267.4 → XP_006526330.1  rho GTPase-activating protein 26 isoform X3

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:714 → 769
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  7. XM_036161288.1 → XP_036017181.1  rho GTPase-activating protein 26 isoform X8

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl17036
    Location:714 → 740
    SH3; Src Homology 3 domain superfamily

  8. XM_030250608.2 → XP_030106468.1  rho GTPase-activating protein 26 isoform X7

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (3) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  9. XM_036161287.1 → XP_036017180.1  rho GTPase-activating protein 26 isoform X6

    UniProtKB/TrEMBL
    B9EJ96
    Conserved Domains (4) summary
    cd12064
    Location:634 → 689
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:284 → 483
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:187 → 291
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 145
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ82.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ82

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