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NGEF neuronal guanine nucleotide exchange factor [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 713917, updated on 17-Aug-2024

Summary

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Official Symbol
NGEFprovided by VGNC
Official Full Name
neuronal guanine nucleotide exchange factorprovided by VGNC
Primary source
VGNC:VGNC:75345
See related
Ensembl:ENSMMUG00000012216
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NGEF in Genome Data Viewer
Location:
chromosome: 12
Exon count:
18
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (120318012..120454297, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (115409945..115543790, complement)

Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene uncharacterized LOC114671440 Neighboring gene neuraminidase 2 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene uncharacterized LOC114671442

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ephexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041765.1 Reference Mmul_10 Primary Assembly

    Range
    120318012..120454297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028831238.1 → XP_028687071.1  ephexin-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5REE7, F6VMG6, H9FSI9
    Related
    ENSMMUP00000058690.2, ENSMMUT00000071621.2
    Conserved Domains (3) summary
    cd11939
    Location:523 → 577
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:384 → 510
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:184 → 362
    RhoGEF; RhoGEF domain

  2. XM_001114604.4 → XP_001114604.1  ephexin-1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5R9A9, G7N973
    Related
    ENSMMUP00000056900.2, ENSMMUT00000054517.2
    Conserved Domains (4) summary
    cd11939
    Location:618 → 672
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:479 → 605
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:492 → 598
    PH; PH domain
    pfam00621
    Location:279 → 458
    RhoGEF; RhoGEF domain

  3. XM_028831239.1 → XP_028687072.1  ephexin-1 isoform X3

    UniProtKB/TrEMBL
    F6VMG6
    Conserved Domains (3) summary
    cd11939
    Location:457 → 511
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:318 → 444
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 296
    RhoGEF; RhoGEF domain

  4. XM_028831240.1 → XP_028687073.1  ephexin-1 isoform X3

    UniProtKB/TrEMBL
    F6VMG6
    Related
    ENSMMUP00000016020.3, ENSMMUT00000017106.4
    Conserved Domains (3) summary
    cd11939
    Location:457 → 511
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:318 → 444
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 296
    RhoGEF; RhoGEF domain
Nucleotide Protein
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