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Tmem80 transmembrane protein 80 [ Mus musculus (house mouse) ]

Gene ID: 71448, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem80provided by MGI
Official Full Name
transmembrane protein 80provided by MGI
Primary source
MGI:MGI:1918698
See related
Ensembl:ENSMUSG00000025505 AllianceGenome:MGI:1918698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5530601I19Rik
Summary
Predicted to be involved in non-motile cilium assembly. Located in ciliary transition zone. Orthologous to human TMEM80 (transmembrane protein 80). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 8.6), thymus adult (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem80 in Genome Data Viewer
Location:
7 F5; 7 86.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140908046..140917069)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141328130..141337156)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dopamine receptor D4 Neighboring gene DEAF1, transcription factor Neighboring gene STARR-seq mESC enhancer starr_20486 Neighboring gene predicted gene, 53347 Neighboring gene STARR-positive B cell enhancer ABC_E4985 Neighboring gene EPS8-like 2 Neighboring gene RIKEN cDNA B230206H07 gene Neighboring gene STARR-seq mESC enhancer starr_20489 Neighboring gene predicted gene, 25725

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. Li C, et al. PLoS Biol, 2016 Mar. PMID 26982032, Free PMC Article
  2. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141950.2 → NP_001135422.1  transmembrane protein 80 isoform 1

    See identical proteins and their annotated locations for NP_001135422.1

    Status: VALIDATED

    Source sequence(s)
    AC163434
    Consensus CDS
    CCDS22008.1
    UniProtKB/Swiss-Prot
    Q8BQL4, Q9D3H0
    Related
    ENSMUSP00000026578.8, ENSMUST00000026578.14
    Conserved Domains (1) summary
    pfam09799
    Location:4 → 107
    Transmemb_17; Predicted membrane protein

  2. NM_001374020.2 → NP_001360949.1  transmembrane protein 80 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163434
    Conserved Domains (1) summary
    pfam09799
    Location:24 → 127
    Transmemb_17; Predicted membrane protein

  3. NM_001374021.2 → NP_001360950.1  transmembrane protein 80 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163434
    Conserved Domains (1) summary
    pfam09799
    Location:24 → 96
    Transmemb_17; Predicted membrane protein

  4. NM_027797.4 → NP_082073.1  transmembrane protein 80 isoform 1

    See identical proteins and their annotated locations for NP_082073.1

    Status: VALIDATED

    Source sequence(s)
    AC163434
    Consensus CDS
    CCDS22008.1
    UniProtKB/Swiss-Prot
    Q8BQL4, Q9D3H0
    Related
    ENSMUSP00000116695.2, ENSMUST00000133012.8
    Conserved Domains (1) summary
    pfam09799
    Location:4 → 107
    Transmemb_17; Predicted membrane protein

RNA

  1. NR_024509.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163434
    Related
    ENSMUST00000128649.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140908046..140917069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249858.2 → XP_011248160.1  transmembrane protein 80 isoform X1

    See identical proteins and their annotated locations for XP_011248160.1

    UniProtKB/Swiss-Prot
    Q8BQL4, Q9D3H0
    Conserved Domains (1) summary
    pfam09799
    Location:4 → 107
    Transmemb_17; Predicted membrane protein

  2. XM_036153437.1 → XP_036009330.1  transmembrane protein 80 isoform X1

    UniProtKB/Swiss-Prot
    Q8BQL4, Q9D3H0
    Related
    ENSMUSP00000123330.2, ENSMUST00000126510.8
    Conserved Domains (1) summary
    pfam09799
    Location:4 → 107
    Transmemb_17; Predicted membrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3H0.1 GenPept UniProtKB/Swiss-Prot:Q9D3H0

Gene LinkOut

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