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Tmem248 transmembrane protein 248 [ Mus musculus (house mouse) ]

Gene ID: 71667, updated on 28-Oct-2024

Summary

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Official Symbol
Tmem248provided by MGI
Official Full Name
transmembrane protein 248provided by MGI
Primary source
MGI:MGI:1918917
See related
Ensembl:ENSMUSG00000053094 AllianceGenome:MGI:1918917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610007L01Rik; A930023A16Rik; G430067H08Rik
Summary
Predicted to be located in membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mesenteric adipose tissue. Orthologous to human TMEM248 (transmembrane protein 248). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 24.3), adrenal adult (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem248 in Genome Data Viewer
Location:
5 G1.3; 5 68.91 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130248585..130272606)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130219744..130243765)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10356 Neighboring gene STARR-seq mESC enhancer starr_14472 Neighboring gene predicted gene 15921 Neighboring gene STARR-positive B cell enhancer ABC_E11304 Neighboring gene STARR-positive B cell enhancer ABC_E11728 Neighboring gene predicted gene 6598 Neighboring gene STARR-positive B cell enhancer mm9_chr5:130730118-130730418 Neighboring gene STARR-positive B cell enhancer ABC_E234 Neighboring gene STARR-positive B cell enhancer ABC_E279 Neighboring gene SBDS ribosome maturation factor Neighboring gene tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_14473

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 248
Names
UPF0458 protein C7orf42 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081394.1 → NP_001074863.1  transmembrane protein 248

    See identical proteins and their annotated locations for NP_001074863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC113029
    Consensus CDS
    CCDS39295.1
    UniProtKB/Swiss-Prot
    Q3TBN1, Q8CIB2, Q9DD07
    Related
    ENSMUSP00000067501.7, ENSMUST00000065329.13
    Conserved Domains (1) summary
    pfam14940
    Location:10 → 256
    TMEM219; Transmembrane 219

  2. NM_027854.1 → NP_082130.1  transmembrane protein 248

    See identical proteins and their annotated locations for NP_082130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC113029, AK142176, CN526906
    Consensus CDS
    CCDS39295.1
    UniProtKB/Swiss-Prot
    Q3TBN1, Q8CIB2, Q9DD07
    Related
    ENSMUSP00000106929.5, ENSMUST00000111298.6
    Conserved Domains (1) summary
    pfam14940
    Location:10 → 256
    TMEM219; Transmembrane 219

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    130248585..130272606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240907.4 → XP_011239209.1  transmembrane protein 248 isoform X1

    See identical proteins and their annotated locations for XP_011239209.1

    UniProtKB/Swiss-Prot
    Q3TBN1, Q8CIB2, Q9DD07
    Conserved Domains (1) summary
    pfam14940
    Location:10 → 256
    TMEM219; Transmembrane 219

  2. XM_030254810.1 → XP_030110670.1  transmembrane protein 248 isoform X1

    UniProtKB/Swiss-Prot
    Q3TBN1, Q8CIB2, Q9DD07
    Conserved Domains (1) summary
    pfam14940
    Location:10 → 256
    TMEM219; Transmembrane 219

  3. XM_030254811.2 → XP_030110671.1  transmembrane protein 248 isoform X1

    UniProtKB/Swiss-Prot
    Q3TBN1, Q8CIB2, Q9DD07
    Conserved Domains (1) summary
    pfam14940
    Location:10 → 256
    TMEM219; Transmembrane 219
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TBN1.1 GenPept UniProtKB/Swiss-Prot:Q3TBN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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