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Osbpl3 oxysterol binding protein-like 3 [ Mus musculus (house mouse) ]

Gene ID: 71720, updated on 2-Nov-2024

Summary

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Official Symbol
Osbpl3provided by MGI
Official Full Name
oxysterol binding protein-like 3provided by MGI
Primary source
MGI:MGI:1918970
See related
Ensembl:ENSMUSG00000029822 AllianceGenome:MGI:1918970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORP3; ORP-3; OSBP3; A530055M08; 1200014M06Rik; 6720421I08Rik
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in endoplasmic reticulum membrane and filopodium tip. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; immune system; olfactory epithelium; and respiratory system. Orthologous to human OSBPL3 (oxysterol binding protein like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 12.7), kidney adult (RPKM 6.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Osbpl3 in Genome Data Viewer
Location:
6 B2.3; 6 24.13 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (50270307..50433334, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (50293327..50456354, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15840 Neighboring gene predicted gene, 38805 Neighboring gene STARR-seq mESC enhancer starr_15842 Neighboring gene protein associated with LIN7 2, MAGUK family member Neighboring gene STARR-seq mESC enhancer starr_15843 Neighboring gene gasdermin E Neighboring gene STARR-positive B cell enhancer mm9_chr6:50244177-50244478 Neighboring gene STARR-seq mESC enhancer starr_15846 Neighboring gene STARR-positive B cell enhancer ABC_E8102 Neighboring gene STARR-seq mESC enhancer starr_15847 Neighboring gene predicted gene, 52900 Neighboring gene predicted gene, 40372 Neighboring gene predicted gene, 53324

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics. Wang X, et al. Cell Mol Life Sci, 2023 Sep 22. PMID 37740130, Free PMC Article
  2. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor. Njeru SN, et al. Oncogene, 2020 Feb. PMID 31659255
  3. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Yan D, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17303778
  4. Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease. Aibara D, et al. Mol Cell Endocrinol, 2023 Apr 5. PMID 36781118
  5. During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes. Revil T, et al. Dev Dyn, 2013 Mar. PMID 23233200

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
    Title: Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
  2. Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor gamma in fatty liver disease.
    Title: Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.
  3. OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.
    Title: Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102333

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium tip IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 3
Names
OSBP-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163645.1 → NP_001157117.1  oxysterol-binding protein-related protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA086565, AK004768, AK040984, AK042104, AK160310, BX524424, CD538704, CF751761
    Consensus CDS
    CCDS51771.1
    UniProtKB/TrEMBL
    F8WH20, Q80UX3
    Related
    ENSMUSP00000071643.5, ENSMUST00000071728.11
    Conserved Domains (3) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:51 → 141
    PH; PH domain
    pfam01237
    Location:459 → 793
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001347213.1 → NP_001334142.1  oxysterol-binding protein-related protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008160, AC124689
    Consensus CDS
    CCDS85046.1
    UniProtKB/TrEMBL
    D3YTT6, Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:526 → 870
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_027881.3 → NP_082157.2  oxysterol-binding protein-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_082157.2

    Status: VALIDATED

    Source sequence(s)
    AA086565, AK004768, AK040984, AK042104, BX524424, CD538704, CF751761
    Consensus CDS
    CCDS39489.1
    UniProtKB/Swiss-Prot
    E9QNI5, Q9DBS9
    UniProtKB/TrEMBL
    Q80UX3
    Related
    ENSMUSP00000110112.3, ENSMUST00000114468.9
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:495 → 839
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    50270307..50433334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255598.1 → XP_030111458.1  oxysterol-binding protein-related protein 3 isoform X3

    UniProtKB/TrEMBL
    D3Z194, Q80UX3
    Related
    ENSMUSP00000110110.2, ENSMUST00000114466.8
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:490 → 834
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_006506630.3 → XP_006506693.1  oxysterol-binding protein-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006506693.1

    UniProtKB/TrEMBL
    D3YTT6, Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:526 → 870
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_006506633.5 → XP_006506696.1  oxysterol-binding protein-related protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006506696.1

    UniProtKB/Swiss-Prot
    E9QNI5, Q9DBS9
    UniProtKB/TrEMBL
    Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:495 → 839
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_006506634.5 → XP_006506697.1  oxysterol-binding protein-related protein 3 isoform X3

    UniProtKB/TrEMBL
    D3Z194, Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:490 → 834
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_030255597.2 → XP_030111457.1  oxysterol-binding protein-related protein 3 isoform X3

    UniProtKB/TrEMBL
    D3Z194, Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:490 → 834
    Oxysterol_BP; Oxysterol-binding protein

  6. XM_011241468.4 → XP_011239770.1  oxysterol-binding protein-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011239770.1

    UniProtKB/TrEMBL
    D3YTT6, Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:526 → 870
    Oxysterol_BP; Oxysterol-binding protein

  7. XM_006506635.4 → XP_006506698.1  oxysterol-binding protein-related protein 3 isoform X4

    UniProtKB/TrEMBL
    Q80UX3
    Conserved Domains (2) summary
    cd13287
    Location:30 → 127
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:363 → 707
    Oxysterol_BP; Oxysterol-binding protein

  8. XM_030255599.2 → XP_030111459.1  oxysterol-binding protein-related protein 3 isoform X6

    Conserved Domains (1) summary
    pfam01237
    Location:127 → 471
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_006506631.5 → XP_006506694.1  oxysterol-binding protein-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006506694.1

    UniProtKB/TrEMBL
    D3YTT6, Q80UX3
    Related
    ENSMUSP00000087473.4, ENSMUST00000090019.10
    Conserved Domains (2) summary
    cd13287
    Location:30 → 152
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:526 → 870
    Oxysterol_BP; Oxysterol-binding protein

  10. XM_006506636.4 → XP_006506699.1  oxysterol-binding protein-related protein 3 isoform X5

    Conserved Domains (1) summary
    pfam01237
    Location:163 → 507
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBS9.2 GenPept UniProtKB/Swiss-Prot:Q9DBS9

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