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Cic capicua transcriptional repressor [ Mus musculus (house mouse) ]

Gene ID: 71722, updated on 2-Nov-2024

Summary

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Official Symbol
Cicprovided by MGI
Official Full Name
capicua transcriptional repressorprovided by MGI
Primary source
MGI:MGI:1918972
See related
Ensembl:ENSMUSG00000005442 AllianceGenome:MGI:1918972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0306; 1200010B10Rik
Summary
Enables chromatin binding activity. Involved in several processes, including learning or memory; negative regulation of DNA-templated transcription; and social behavior. Acts upstream of or within lung alveolus development and negative regulation of transcription by RNA polymerase II. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; hemolymphoid system; and urinary system. Used to study disease of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 35.3), adrenal adult (RPKM 24.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cic in Genome Data Viewer
Location:
7 A3; 7 13.73 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24967054..24993584)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25267658..25294159)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ets2 repressor factor Neighboring gene STARR-positive B cell enhancer ABC_E3706 Neighboring gene predicted gene, 53354 Neighboring gene STARR-seq mESC enhancer starr_18298 Neighboring gene STARR-positive B cell enhancer ABC_E348 Neighboring gene STARR-positive B cell enhancer ABC_E24 Neighboring gene predicted gene, 45974 Neighboring gene STARR-seq mESC enhancer starr_18299 Neighboring gene STARR-positive B cell enhancer ABC_E8154 Neighboring gene STARR-positive B cell enhancer ABC_E2226 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_18300 Neighboring gene proline rich 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Whole-genome landscape of adult T-cell leukemia/lymphoma. Kogure Y, et al. Blood, 2022 Feb 17. PMID 34695199, Free PMC Article
  2. Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1. Chopra R, et al. Hum Mol Genet, 2020 Nov 25. PMID 32964235, Free PMC Article
  3. Deficiency of Capicua disrupts bile acid homeostasis. Kim E, et al. Sci Rep, 2015 Feb 5. PMID 25653040, Free PMC Article
  4. CIC is a critical regulator of neuronal differentiation. Hwang I, et al. JCI Insight, 2020 May 7. PMID 32229723, Free PMC Article
  5. Severe developmental bone phenotype in ClC-7 deficient mice. Neutzsky-Wulff AV, et al. Dev Biol, 2010 Aug 15. PMID 20599900

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis.
    Title: Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis.
  2. Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua.
    Title: Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua.
  3. Capicua regulates the development of adult-born neurons in the hippocampus.
    Title: Capicua regulates the development of adult-born neurons in the hippocampus.
  4. Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.
    Title: Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.
  5. CIC is a critical regulator of neuronal differentiation.
    Title: CIC is a critical regulator of neuronal differentiation.
  6. Derepression of Etv5 increases Hobit expression in Cic -deficient CD8+ T cells and consequently enhances CD8+ T memory cell formation in liver, thereby leading to liver injury.
    Title: The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8(+) T-Cell Development and the Pathogenesis of Liver Injury.
  7. CIC is a transcriptional repressor of genes regulated by MAPK signaling.
    Title: The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.
  8. these results identify Cic as an important regulator of cell fate in neurodevelopment and oligodendroglioma, and suggest that its loss contributes to oligodendroglioma by promoting proliferation and an oligodendrocyte precursor cells -like identity via Ets overactivity.
    Title: Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors.
  9. maintains T-cell homeostasis and negatively regulates follicular helper T cell development and autoimmunity
    Title: Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
  10. Loss of CIC causes T cell lymphoblastic leukemia/lymphoma.
    Title: Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung alveolus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein capicua homolog
Names
capicua homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302811.1 → NP_001289740.1  protein capicua homolog isoform CIC-L

    See identical proteins and their annotated locations for NP_001289740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate promoter, an alternate start codon, and has multiple differences in the coding region compared to variant 1. It encodes isoform CIC-L (PMID: 17190598), which has a distinct N-terminus and is longer than isoform CIC-S.
    Source sequence(s)
    AC156992, AK147535, BF455793
    Consensus CDS
    CCDS80678.1
    UniProtKB/Swiss-Prot
    Q3UH79, Q3UHP4, Q6PDJ8, Q8CGE4, Q8CHH0, Q924A2, Q9CW61
    Related
    ENSMUSP00000132351.2, ENSMUST00000169266.8
    Conserved Domains (3) summary
    COG5648
    Location:1063 → 1222
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1106 → 1177
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam16090
    Location:253 → 342
    DUF4819; Domain of unknown function (DUF4819)

  2. NM_027882.4 → NP_082158.2  protein capicua homolog isoform CIC-S

    See identical proteins and their annotated locations for NP_082158.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (CIC-S, PMID: 17190598).
    Source sequence(s)
    AC156992, AK147276, BF455793
    Consensus CDS
    CCDS52146.1
    UniProtKB/Swiss-Prot
    Q924A2
    Related
    ENSMUSP00000126659.2, ENSMUST00000163320.8
    Conserved Domains (2) summary
    COG5648
    Location:156 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24967054..24993584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250697.4 → XP_011248999.1  protein capicua homolog isoform X2

    See identical proteins and their annotated locations for XP_011248999.1

    Conserved Domains (4) summary
    PHA03247
    Location:1671 → 2172
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1063 → 1222
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1106 → 1177
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:253 → 342
    DUF4819; Domain of unknown function (DUF4819)

  2. XM_017312309.2 → XP_017167798.1  protein capicua homolog isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:1671 → 2171
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1063 → 1222
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1106 → 1177
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:253 → 342
    DUF4819; Domain of unknown function (DUF4819)

  3. XM_011250696.3 → XP_011248998.1  protein capicua homolog isoform X2

    See identical proteins and their annotated locations for XP_011248998.1

    Conserved Domains (4) summary
    PHA03247
    Location:1671 → 2172
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1063 → 1222
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1106 → 1177
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:253 → 342
    DUF4819; Domain of unknown function (DUF4819)

  4. XM_036153438.1 → XP_036009331.1  protein capicua homolog isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:1671 → 2172
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1063 → 1222
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1106 → 1177
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:253 → 342
    DUF4819; Domain of unknown function (DUF4819)

  5. XM_017312310.1 → XP_017167799.1  protein capicua homolog isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:1671 → 2172
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1063 → 1222
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:1106 → 1177
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam16090
    Location:253 → 342
    DUF4819; Domain of unknown function (DUF4819)

  6. XM_030242991.1 → XP_030098851.1  protein capicua homolog isoform X9

    Conserved Domains (3) summary
    PHA03247
    Location:609 → 1110
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1 → 160
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:44 → 115
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  7. XM_036153442.1 → XP_036009335.1  protein capicua homolog isoform X10

    Conserved Domains (3) summary
    PHA03247
    Location:609 → 1109
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:1 → 160
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd01388
    Location:44 → 115
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  8. XM_036153441.1 → XP_036009334.1  protein capicua homolog isoform X8

    Related
    ENSMUST00000167379.2
    Conserved Domains (4) summary
    PHA03247
    Location:742 → 1243
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:134 → 293
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK07764
    Location:7 → 117
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01388
    Location:177 → 248
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  9. XM_006540368.2 → XP_006540431.1  protein capicua homolog isoform X5

    Conserved Domains (4) summary
    PHA03247
    Location:764 → 1265
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:156 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK07764
    Location:29 → 139
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  10. XM_036153439.1 → XP_036009332.1  protein capicua homolog isoform X6

    UniProtKB/TrEMBL
    E9QP01
    Related
    ENSMUSP00000005578.7, ENSMUST00000005578.13
    Conserved Domains (4) summary
    PHA03247
    Location:764 → 1265
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:156 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK07764
    Location:29 → 139
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  11. XM_036153440.1 → XP_036009333.1  protein capicua homolog isoform X7

    Conserved Domains (4) summary
    PHA03247
    Location:764 → 1264
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:156 → 315
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK07764
    Location:29 → 139
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01388
    Location:199 → 270
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  12. XM_006540367.1 → XP_006540430.1  protein capicua homolog isoform X4

    Conserved Domains (4) summary
    PHA03247
    Location:765 → 1266
    PHA03247; large tegument protein UL36; Provisional
    COG5648
    Location:157 → 316
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    PRK07764
    Location:30 → 140
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01388
    Location:200 → 271
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001110131.1: Suppressed sequence

    Description
    NM_001110131.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001110132.1: Suppressed sequence

    Description
    NM_001110132.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924A2.2 GenPept UniProtKB/Swiss-Prot:Q924A2

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