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Aox3 aldehyde oxidase 3 [ Mus musculus (house mouse) ]

Gene ID: 71724, updated on 2-Nov-2024

Summary

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Official Symbol
Aox3provided by MGI
Official Full Name
aldehyde oxidase 3provided by MGI
Primary source
MGI:MGI:1918974
See related
Ensembl:ENSMUSG00000064294 AllianceGenome:MGI:1918974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aoh1; Aoh2; 1200011D03Rik
Summary
Enables aldehyde oxidase activity; electron transfer activity; and molybdenum ion binding activity. Predicted to be involved in xenobiotic metabolic process. Located in cytosol. Is expressed in nasal cavity. Orthologous to human AOX3P (aldehyde oxidase 3, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 21.0), liver E18 (RPKM 16.2) and 5 other tissues See more
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Genomic context

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See Aox3 in Genome Data Viewer
Location:
1 C1.3; 1 28.96 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58152294..58241380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58113135..58202221)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene predicted gene, 24548 Neighboring gene aldehyde oxidase 4 Neighboring gene predicted gene 15759 Neighboring gene aldehyde oxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity. Mahro M, et al. PLoS One, 2013. PMID 24358164, Free PMC Article
  2. Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase. Vila R, et al. J Biol Chem, 2004 Mar 5. PMID 14665639
  3. The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity. Coelho C, et al. J Biol Chem, 2012 Nov 23. PMID 23019336, Free PMC Article
  4. Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression. Mahro M, et al. Drug Metab Dispos, 2011 Oct. PMID 21705476
  5. Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. Terao M, et al. J Biol Chem, 2000 Sep 29. PMID 10893244

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
    Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
  2. AOX3 forms a homodimer and each monomer comprises three major domains involved in binding to the cofactors.
    Title: The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.
  3. The recombinant aldehyde oxidase 3 was expressed and purified in a 30% active form, whereas the native aldehyde oxidase 3 is 100% active.
    Title: Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molybdenum ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin cofactor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aldehyde oxidase 3
Names
aldehyde oxidase 1
aldehyde oxidase homolog 1
aldehyde oxidase structural homolog 2
azaheterocycle hydroxylase 3
NP_076106.2
XP_006496347.1
XP_006496348.1
XP_017167859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023617.2 → NP_076106.2  aldehyde oxidase 3

    See identical proteins and their annotated locations for NP_076106.2

    Status: VALIDATED

    Source sequence(s)
    AC025116, AK004700, AK054065, AV275739, BB616838, BX633666
    Consensus CDS
    CCDS14969.1
    UniProtKB/Swiss-Prot
    B2RSI5, G3X982, Q8VI15
    UniProtKB/TrEMBL
    Q9ESH4
    Related
    ENSMUSP00000049391.8, ENSMUST00000040999.14
    Conserved Domains (6) summary
    TIGR02969
    Location:9 → 1334
    mam_aldehyde_ox; aldehyde oxidase
    smart01008
    Location:594 → 697
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam00941
    Location:239 → 419
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:91 → 162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:709 → 1241
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:426 → 530
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58152294..58241380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496285.4 → XP_006496348.1  aldehyde oxidase 3 isoform X2

    UniProtKB/TrEMBL
    Q9ESH4
    Conserved Domains (1) summary
    TIGR02969
    Location:1 → 1211
    mam_aldehyde_ox; aldehyde oxidase

  2. XM_006496284.5 → XP_006496347.1  aldehyde oxidase 3 isoform X1

    UniProtKB/TrEMBL
    Q9ESH4
    Conserved Domains (1) summary
    TIGR02969
    Location:1 → 1277
    mam_aldehyde_ox; aldehyde oxidase

  3. XM_017312370.3 → XP_017167859.1  aldehyde oxidase 3 isoform X3

    UniProtKB/TrEMBL
    Q9CW59
    Conserved Domains (1) summary
    TIGR02969
    Location:1 → 1110
    mam_aldehyde_ox; aldehyde oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3X982.1 GenPept UniProtKB/Swiss-Prot:G3X982

Gene LinkOut

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