Susd2 sushi domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Susd2provided by MGI
Official Full Name: sushi domain containing 2provided by MGI
Primary source: MGI:MGI:1918983
See related: Ensembl:ENSMUSG00000006342 AllianceGenome:MGI:1918983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200011D11Rik
Summary: Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of cell division. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in ganglia; hindbrain; urinary system; and ventral grey horn. Orthologous to human SUSD2 (sushi domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 75.6), small intestine adult (RPKM 56.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.56 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75472453..75479842, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75636619..75644008, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUSD2 suppresses CD8<sup>+</sup> T cell antitumor immunity by targeting IL-2 receptor signaling.
Title: SUSD2 suppresses CD8(+) T cell antitumor immunity by targeting IL-2 receptor signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sushi domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162913.1 → NP_001156385.1 sushi domain-containing protein 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001156385.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC087540, BB632717, BC026837

Consensus CDS

CCDS48600.1

UniProtKB/Swiss-Prot

Q9DBX3

Related

ENSMUSP00000076802.5, ENSMUST00000077610.6

Conserved Domains (3) summary

cd00033
Location:602 → 656

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00216
Location:324 → 489

VWD; von Willebrand factor (vWF) type D domain

pfam03782
Location:166 → 308

AMOP; AMOP domain
NM_027890.5 → NP_082166.3 sushi domain-containing protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_082166.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC087540, BB632717, BC026837

Consensus CDS

CCDS23929.1

UniProtKB/Swiss-Prot

Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179, Q9DBX3

Related

ENSMUSP00000093197.4, ENSMUST00000095541.11

Conserved Domains (4) summary

cd00033
Location:722 → 776

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00216
Location:444 → 609

VWD; von Willebrand factor (vWF) type D domain

pfam01033
Location:27 → 62

Somatomedin_B; Somatomedin B domain

pfam03782
Location:286 → 428

AMOP; AMOP domain