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Coasy Coenzyme A synthase [ Mus musculus (house mouse) ]

Gene ID: 71743, updated on 2-Nov-2024

Summary

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Official Symbol
Coasyprovided by MGI
Official Full Name
Coenzyme A synthaseprovided by MGI
Primary source
MGI:MGI:1918993
See related
Ensembl:ENSMUSG00000001755 AllianceGenome:MGI:1918993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dpck; Ppat; Ukr1; 1300003G02Rik
Summary
This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in adrenal adult (RPKM 70.2), liver adult (RPKM 63.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Coasy in Genome Data Viewer
Location:
11 D; 11 64.17 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100973391..100977445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101082565..101086619)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8456 Neighboring gene alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100943626-100943809 Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene MAX-like protein X Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CoA synthase plays a critical role in neurodevelopment and neurodegeneration. Cavestro C, et al. Front Cell Neurosci, 2024. PMID 39301217, Free PMC Article
  2. Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Di Meo I, et al. Int J Mol Sci, 2020 Dec 19. PMID 33352696, Free PMC Article
  3. Subcellular localization and regulation of coenzyme A synthase. Zhyvoloup A, et al. J Biol Chem, 2003 Dec 12. PMID 14514684
  4. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis. Zhyvoloup A, et al. J Biol Chem, 2002 Jun 21. PMID 11980892
  5. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). Aghajanian S, et al. Biochem J, 2002 Jul 1. PMID 11994049, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.
    Title: Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dephospho-CoA kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dephospho-CoA kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables pantetheine-phosphate adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantetheine-phosphate adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pantetheine-phosphate adenylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pantetheine-phosphate adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bifunctional coenzyme A synthase
Names
4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase
CoA synthase
NP_001292911.1
XP_006534319.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305982.1 → NP_001292911.1  bifunctional coenzyme A synthase precursor

    See identical proteins and their annotated locations for NP_001292911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AK004878, AK159405, BB872569, BC064753
    Consensus CDS
    CCDS25446.1
    UniProtKB/Swiss-Prot
    A2BFA8, Q3TVZ2, Q8K3Y4, Q9DBL7
    Related
    ENSMUSP00000001806.4, ENSMUST00000001806.10
    Conserved Domains (3) summary
    cd02164
    Location:192 → 338
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    COG0237
    Location:358 → 557
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cd02022
    Location:359 → 535
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

RNA

  1. NR_155015.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. . This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria
    Source sequence(s)
    BX255926

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100973391..100977445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534256.2 → XP_006534319.1  bifunctional coenzyme A synthase isoform X1

    Conserved Domains (2) summary
    cd02022
    Location:133 → 309
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
    cl00015
    Location:5 → 112
    nt_trans; nucleotidyl transferase superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027896.4: Suppressed sequence

    Description
    NM_027896.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBL7.2 GenPept UniProtKB/Swiss-Prot:Q9DBL7

Gene LinkOut

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