Tha1 threonine aldolase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tha1provided by MGI
Official Full Name: threonine aldolase 1provided by MGI
Primary source: MGI:MGI:1919026
See related: Ensembl:ENSMUSG00000017713 AllianceGenome:MGI:1919026
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLY1; 1300017K07Rik
Summary: Predicted to enable L-allo-threonine aldolase activity. Predicted to be involved in glycine biosynthetic process and threonine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human THA1P (threonine aldolase 1, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 19.6), adrenal adult (RPKM 18.8) and 24 other tissues See more
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Genomic context

Location:: 11 E2; 11 82.96 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (117758775..117764352, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (117867949..117873526, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice, the western-clawed frog and the zebrafish have transcribed threonine aldolase/GLY1 genes, but the human homolog is a non-transcribed pseudogene
Title: Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tha1 (e-PCR), detects polymorphism
- UniSTS:471109

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-allo-threonine aldolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in glycine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in threonine catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: threonine aldolase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027919.5 → NP_082195.2 threonine aldolase 1

See identical proteins and their annotated locations for NP_082195.2

Status: VALIDATED

Source sequence(s)

AL591433

Consensus CDS

CCDS48993.1

UniProtKB/TrEMBL

Q6XPS7

Related

ENSMUSP00000033230.8, ENSMUST00000033230.8

Conserved Domains (1) summary

cl18945
Location:40 → 388

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

117758775..117764352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534261.3 → XP_006534324.1 threonine aldolase 1 isoform X1

Conserved Domains (1) summary

cl18945
Location:9 → 264

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...