U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Klhl5 kelch-like 5 [ Mus musculus (house mouse) ]

Gene ID: 71778, updated on 2-Nov-2024

Summary

Official Symbol
Klhl5provided by MGI
Official Full Name
kelch-like 5provided by MGI
Primary source
MGI:MGI:1919028
See related
Ensembl:ENSMUSG00000054920 AllianceGenome:MGI:1919028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300013C10Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including aorta; central nervous system; endocrine gland; esophagus; and limb interdigital region. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human KLHL5 (kelch like family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 16.4), CNS E18 (RPKM 7.3) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Klhl5 in Genome Data Viewer
Location:
5 C3.1; 5 33.58 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65264894..65325490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65107551..65168173)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 114, member A1 Neighboring gene STARR-seq mESC enhancer starr_13253 Neighboring gene STARR-seq mESC enhancer starr_13254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65397377-65397486 Neighboring gene predicted gene, 32374 Neighboring gene STARR-seq mESC enhancer starr_13256 Neighboring gene transmembrane protein 156 Neighboring gene STARR-seq mESC enhancer starr_13258 Neighboring gene STARR-seq mESC enhancer starr_13259 Neighboring gene predicted gene, 54287 Neighboring gene STARR-positive B cell enhancer ABC_E849 Neighboring gene WD repeat domain 19 Neighboring gene STARR-seq mESC enhancer starr_13260 Neighboring gene replication factor C (activator 1) 1 Neighboring gene STARR-positive B cell enhancer ABC_E6334

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347355.1NP_001334284.1  kelch-like protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC132222
    Consensus CDS
    CCDS84883.1
    UniProtKB/TrEMBL
    E9Q1L2, Q571J4
    Related
    ENSMUSP00000144976.2, ENSMUST00000204097.3
  2. NM_001359401.1NP_001346330.1  kelch-like protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC132222, AK090246, BC057606
    Conserved Domains (2) summary
    pfam07707
    Location:275370
    BACK; BTB And C-terminal Kelch
    cl28614
    Location:173370
    BTB; Broad-Complex, Tramtrack and Bric a brac
  3. NM_175174.4NP_780383.2  kelch-like protein 5 isoform 1

    See identical proteins and their annotated locations for NP_780383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI120540, BC057606
    Consensus CDS
    CCDS19305.2
    UniProtKB/TrEMBL
    E9QA66, Q6PFE1
    Related
    ENSMUSP00000098752.4, ENSMUST00000101191.10
    Conserved Domains (6) summary
    smart00612
    Location:562608
    Kelch; Kelch domain
    PHA03098
    Location:173695
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:457500
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:163266
    BTB; BTB/POZ domain
    pfam01344
    Location:456501
    Kelch_1; Kelch motif
    pfam07707
    Location:275374
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65264894..65325490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504134.5XP_006504197.1  kelch-like protein 5 isoform X1

    Conserved Domains (2) summary
    PHA03098
    Location:22495
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:257300
    Kelch; KELCH repeat [structural motif]
  2. XM_006504136.4XP_006504199.1  kelch-like protein 5 isoform X2

    Conserved Domains (2) summary
    cl38908
    Location:150279
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:269372
    BACK; BACK (BTB and C-terminal Kelch) domain
  3. XM_036165496.1XP_036021389.1  kelch-like protein 5 isoform X1

    Conserved Domains (2) summary
    PHA03098
    Location:22495
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:257300
    Kelch; KELCH repeat [structural motif]