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Rnf180 ring finger protein 180 [ Mus musculus (house mouse) ]

Gene ID: 71816, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf180provided by MGI
Official Full Name
ring finger protein 180provided by MGI
Primary source
MGI:MGI:1919066
See related
Ensembl:ENSMUSG00000021720 AllianceGenome:MGI:1919066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rines; 3110001E11Rik
Summary
Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including norepinephrine metabolic process; positive regulation of protein metabolic process; and serotonin metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal medulla; central nervous system; genitourinary system; lens; and thymus. Orthologous to human RNF180 (ring finger protein 180). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 6.2), CNS E18 (RPKM 4.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf180 in Genome Data Viewer
Location:
13 56.92 cM; 13 D1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (105267075..105431406, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (105130567..105294818, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 7 binding protein Neighboring gene 5' nucleotidase, ecto-like Neighboring gene STARR-positive B cell enhancer ABC_E7275 Neighboring gene STARR-seq mESC enhancer starr_35548 Neighboring gene STARR-seq mESC enhancer starr_35549 Neighboring gene predicted gene, 25631 Neighboring gene STARR-seq mESC enhancer starr_35551 Neighboring gene predicted gene, 41049 Neighboring gene predicted gene, 31130

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice. Wang K, et al. Arch Pharm Res, 2024 Jul. PMID 39060657
  2. RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination. Zhao Q, et al. Cell Cycle, 2023 May. PMID 37095741, Free PMC Article
  3. Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses. Kabayama M, et al. J Neurosci, 2013 Aug 7. PMID 23926250, Free PMC Article
  4. Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Ogawa M, et al. Genes Cells, 2008 Apr. PMID 18363970
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice.
    Title: E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice.
  2. RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination.
    Title: RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination.
  3. Rines is a critical regulator of the monoaminergic system and emotional behavior and identify a promising candidate drug target for treating diseases associated with emotion.
    Title: Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.
  4. The involvement of RNF180 in the ubiquitin-proteasome pathway was further supported by its binding to the UbcH6 ubiquitin-conjugating enzyme and by its trans-ubiquitination enhancing activities.
    Title: Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in norepinephrine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within norepinephrine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in serotonin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within serotonin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF180
Names
RING-type E3 ubiquitin transferase RNF180
NP_001347819.1
NP_001347820.1
NP_082210.1
XP_006517819.1
XP_006517822.1
XP_006517823.1
XP_006517824.4
XP_011242998.2
XP_017171096.1
XP_030103272.1
XP_030103273.1
XP_030103274.1
XP_036014060.1
XP_036014061.1
XP_036014062.1
XP_036014063.1
XP_036014064.1
XP_036014065.1
XP_036014066.1
XP_036014067.1
XP_036014068.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360890.1 → NP_001347819.1  E3 ubiquitin-protein ligase RNF180 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154203, BC075700
    Consensus CDS
    CCDS88517.1
    Related
    ENSMUSP00000153478.2, ENSMUST00000226044.2
    Conserved Domains (1) summary
    cd16554
    Location:431 → 473
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  2. NM_001360891.1 → NP_001347820.1  E3 ubiquitin-protein ligase RNF180 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154203, AC175380, AK151379, CJ302269
    Consensus CDS
    CCDS88518.1
    UniProtKB/Swiss-Prot
    Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
    Related
    ENSMUSP00000153506.2, ENSMUST00000224662.2
    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  3. NM_027934.2 → NP_082210.1  E3 ubiquitin-protein ligase RNF180 isoform 1

    See identical proteins and their annotated locations for NP_082210.1

    Status: VALIDATED

    Source sequence(s)
    AK136632
    Consensus CDS
    CCDS36775.1
    UniProtKB/Swiss-Prot
    Q3U827
    Related
    ENSMUSP00000153678.2, ENSMUST00000224011.2
    Conserved Domains (1) summary
    cd00162
    Location:431 → 477
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    105267075..105431406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247413.2 → XP_030103273.1  E3 ubiquitin-protein ligase RNF180 isoform X5

    UniProtKB/Swiss-Prot
    Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  2. XM_017315607.3 → XP_017171096.1  E3 ubiquitin-protein ligase RNF180 isoform X6

    UniProtKB/Swiss-Prot
    Q3U827
    Conserved Domains (1) summary
    cd16554
    Location:431 → 473
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  3. XM_006517759.5 → XP_006517822.1  E3 ubiquitin-protein ligase RNF180 isoform X5

    See identical proteins and their annotated locations for XP_006517822.1

    UniProtKB/Swiss-Prot
    Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  4. XM_030247414.1 → XP_030103274.1  E3 ubiquitin-protein ligase RNF180 isoform X6

    Conserved Domains (1) summary
    cd16554
    Location:431 → 473
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  5. XM_030247412.1 → XP_030103272.1  E3 ubiquitin-protein ligase RNF180 isoform X4

    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  6. XM_006517756.4 → XP_006517819.1  E3 ubiquitin-protein ligase RNF180 isoform X3

    Conserved Domains (1) summary
    cd16554
    Location:433 → 475
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  7. XM_006517760.3 → XP_006517823.1  E3 ubiquitin-protein ligase RNF180 isoform X5

    See identical proteins and their annotated locations for XP_006517823.1

    UniProtKB/Swiss-Prot
    Q3U827, Q3UW39, Q80ZX1, Q8CCR1, Q9CXV6
    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  8. XM_006517761.5 → XP_006517824.4  E3 ubiquitin-protein ligase RNF180 isoform X1

    Conserved Domains (1) summary
    cd16554
    Location:481 → 523
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  9. XM_011244696.4 → XP_011242998.2  E3 ubiquitin-protein ligase RNF180 isoform X2

    Conserved Domains (1) summary
    cd16554
    Location:480 → 522
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  10. XM_036158170.1 → XP_036014063.1  E3 ubiquitin-protein ligase RNF180 isoform X9

    Conserved Domains (1) summary
    cd16554
    Location:431 → 473
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  11. XM_036158171.1 → XP_036014064.1  E3 ubiquitin-protein ligase RNF180 isoform X9

    Conserved Domains (1) summary
    cd16554
    Location:431 → 473
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  12. XM_036158168.1 → XP_036014061.1  E3 ubiquitin-protein ligase RNF180 isoform X8

    Conserved Domains (1) summary
    cd16554
    Location:480 → 522
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  13. XM_036158169.1 → XP_036014062.1  E3 ubiquitin-protein ligase RNF180 isoform X7

    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  14. XM_036158167.1 → XP_036014060.1  E3 ubiquitin-protein ligase RNF180 isoform X7

    Conserved Domains (1) summary
    cd16554
    Location:432 → 474
    RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

  15. XM_036158175.1 → XP_036014068.1  E3 ubiquitin-protein ligase RNF180 isoform X12

  16. XM_036158172.1 → XP_036014065.1  E3 ubiquitin-protein ligase RNF180 isoform X10

  17. XM_036158174.1 → XP_036014067.1  E3 ubiquitin-protein ligase RNF180 isoform X12

  18. XM_036158173.1 → XP_036014066.1  E3 ubiquitin-protein ligase RNF180 isoform X11

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U827.2 GenPept UniProtKB/Swiss-Prot:Q3U827

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