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NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]

Gene ID: 7182, updated on 2-Nov-2024

Summary

Official Symbol
NR2C2provided by HGNC
Official Full Name
nuclear receptor subfamily 2 group C member 2provided by HGNC
Primary source
HGNC:HGNC:7972
See related
Ensembl:ENSG00000177463 MIM:601426; AllianceGenome:HGNC:7972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR4; TAK1
Summary
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

See NR2C2 in Genome Data Viewer
Location:
3p25.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14947583..15049273)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14950033..15051696)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14989090..15090780)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14845672-14846414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14852491-14852991 Neighboring gene long intergenic non-protein coding RNA 2011 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14855464-14855666 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene Sharpr-MPRA regulatory region 8692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14905091-14905672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14920327-14920828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14941355-14942238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14942239-14943121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14955453-14956275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14956276-14957097 Neighboring gene uncharacterized LOC105376963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14962633-14963132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:14963648-14964847 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14965692-14965871 Neighboring gene Sharpr-MPRA regulatory region 15385 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14988241-14988930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14989619-14990306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14990307-14990994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19523 Neighboring gene FGD5 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15066535-15067034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19525 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14100 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15139860-15140724 Neighboring gene rabenosyn, RAB effector Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:15149813-15150312 Neighboring gene ribosomal protein S24 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 2 group C member 2
Names
Nuclear hormone receptor TR4
orphan nuclear receptor TAK1
orphan nuclear receptor TR4
orphan receptor TR4
testicular nuclear receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291694.2NP_001278623.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    See identical proteins and their annotated locations for NP_001278623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090937, AC090954, AI986459, AK290590
    Consensus CDS
    CCDS74905.1
    UniProtKB/Swiss-Prot
    A8K3H5, B6ZGT8, P49116, P55092
    UniProtKB/TrEMBL
    Q6PHZ7
    Related
    ENSP00000388387.1, ENST00000425241.6
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  2. NM_003298.5NP_003289.2  nuclear receptor subfamily 2 group C member 2 isoform 1

    See identical proteins and their annotated locations for NP_003289.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090937, AC090954, AI986459, AK290590, L27586
    Consensus CDS
    CCDS2621.1
    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Related
    ENSP00000320447.6, ENST00000323373.10
    Conserved Domains (2) summary
    cd06952
    Location:380601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    14947583..15049273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448826.1XP_047304782.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  2. XM_047448825.1XP_047304781.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  3. XM_047448830.1XP_047304786.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  4. XM_047448829.1XP_047304785.1  nuclear receptor subfamily 2 group C member 2 isoform X2

  5. XM_011534058.4XP_011532360.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    See identical proteins and their annotated locations for XP_011532360.1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  6. XM_047448836.1XP_047304792.1  nuclear receptor subfamily 2 group C member 2 isoform X7

  7. XM_011534063.4XP_011532365.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    See identical proteins and their annotated locations for XP_011532365.1

    Conserved Domains (2) summary
    cd06952
    Location:394615
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:145231
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  8. XM_011534064.4XP_011532366.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    See identical proteins and their annotated locations for XP_011532366.1

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:380601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  9. XM_047448827.1XP_047304783.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  10. XM_011534065.4XP_011532367.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    See identical proteins and their annotated locations for XP_011532367.1

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:380601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  11. XM_011534061.4XP_011532363.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    See identical proteins and their annotated locations for XP_011532363.1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  12. XM_047448837.1XP_047304793.1  nuclear receptor subfamily 2 group C member 2 isoform X7

  13. XM_047448832.1XP_047304788.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  14. XM_047448838.1XP_047304794.1  nuclear receptor subfamily 2 group C member 2 isoform X8

  15. XM_047448835.1XP_047304791.1  nuclear receptor subfamily 2 group C member 2 isoform X6

  16. XM_011534059.3XP_011532361.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    See identical proteins and their annotated locations for XP_011532361.1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  17. XM_047448831.1XP_047304787.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  18. XM_047448828.1XP_047304784.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  19. XM_047448824.1XP_047304780.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    Conserved Domains (2) summary
    cd06952
    Location:413634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  20. XM_047448834.1XP_047304790.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2
    Related
    ENSP00000483059.1, ENST00000617312.4
  21. XM_011534066.4XP_011532368.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    See identical proteins and their annotated locations for XP_011532368.1

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:380601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  22. XM_047448833.1XP_047304789.1  nuclear receptor subfamily 2 group C member 2 isoform X4

  23. XM_024453739.2XP_024309507.1  nuclear receptor subfamily 2 group C member 2 isoform X9

    Conserved Domains (2) summary
    cd06952
    Location:182403
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cl02596
    Location:119
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    14950033..15051696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347716.1XP_054203691.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  2. XM_054347714.1XP_054203689.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  3. XM_054347721.1XP_054203696.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  4. XM_054347719.1XP_054203694.1  nuclear receptor subfamily 2 group C member 2 isoform X2

  5. XM_054347711.1XP_054203686.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  6. XM_054347728.1XP_054203703.1  nuclear receptor subfamily 2 group C member 2 isoform X7

  7. XM_054347720.1XP_054203695.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  8. XM_054347724.1XP_054203699.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2
  9. XM_054347717.1XP_054203692.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  10. XM_054347725.1XP_054203700.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2
  11. XM_054347713.1XP_054203688.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  12. XM_054347729.1XP_054203704.1  nuclear receptor subfamily 2 group C member 2 isoform X7

  13. XM_054347723.1XP_054203698.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  14. XM_054347730.1XP_054203705.1  nuclear receptor subfamily 2 group C member 2 isoform X8

  15. XM_054347727.1XP_054203702.1  nuclear receptor subfamily 2 group C member 2 isoform X6

  16. XM_054347715.1XP_054203690.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  17. XM_054347722.1XP_054203697.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  18. XM_054347718.1XP_054203693.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  19. XM_054347712.1XP_054203687.1  nuclear receptor subfamily 2 group C member 2 isoform X1

  20. XM_054347726.1XP_054203701.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2
  21. XM_054347731.1XP_054203706.1  nuclear receptor subfamily 2 group C member 2 isoform X9