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Wfdc3 WAP four-disulfide core domain 3 [ Mus musculus (house mouse) ]

Gene ID: 71856, updated on 2-Nov-2024

Summary

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Official Symbol
Wfdc3provided by MGI
Official Full Name
WAP four-disulfide core domain 3provided by MGI
Primary source
MGI:MGI:1923897
See related
Ensembl:ENSMUSG00000076434 AllianceGenome:MGI:1923897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700015L13Rik; 1700127F16Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; epididymis; and lung. Orthologous to human WFDC3 (WAP four-disulfide core domain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 25.7) and genital fat pad adult (RPKM 2.2) See more
Orthologs
human all
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Genomic context

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See Wfdc3 in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164573222..164587914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164731226..164745994, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor, Kunitz type 4 Neighboring gene serine protease inhibitor, Kunitz type 5 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_06333 Neighboring gene STARR-positive B cell enhancer ABC_E417 Neighboring gene ubiquitin-conjugating enzyme E2C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2. Sivashanmugam P, et al. Gene, 2003 Jul 17. PMID 12909348
  2. Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†. Andrade AD, et al. Biol Reprod, 2021 Jan 4. PMID 33034631
  3. Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Bademci G, et al. Proc Natl Acad Sci U S A, 2022 Jun 28. PMID 35727972, Free PMC Article
  4. The evolution of a genetic locus encoding small serine proteinase inhibitors. Clauss A, et al. Biochem Biophys Res Commun, 2005 Jul 29. PMID 15950183, Free PMC Article
  5. Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Kelleher AM, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28049832, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WAP four-disulfide core domain protein 3
Names
putative protease inhibitor WAP14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418734.1 → NP_001405663.1  WAP four-disulfide core domain protein 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591127
    UniProtKB/Swiss-Prot
    Q14AE4

  2. NM_001418735.1 → NP_001405664.1  WAP four-disulfide core domain protein 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591127
    UniProtKB/Swiss-Prot
    Q14AE4

  3. NM_027961.2 → NP_082237.1  WAP four-disulfide core domain protein 3 precursor

    See identical proteins and their annotated locations for NP_082237.1

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Consensus CDS
    CCDS17053.1
    UniProtKB/Swiss-Prot
    Q14AE4
    Related
    ENSMUSP00000099385.4, ENSMUST00000103096.10
    Conserved Domains (1) summary
    pfam00095
    Location:23 → 58
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RNA

  1. NR_184809.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Related
    ENSMUST00000109328.8

  2. NR_184810.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Related
    ENSMUST00000130227.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164573222..164587914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500193.3 → XP_006500256.1  WAP four-disulfide core domain protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006500256.1

    UniProtKB/Swiss-Prot
    Q14AE4
    Conserved Domains (1) summary
    pfam00095
    Location:23 → 58
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

  2. XM_036162576.1 → XP_036018469.1  WAP four-disulfide core domain protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14AE4
    Conserved Domains (1) summary
    pfam00095
    Location:23 → 58
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

  3. XM_030252094.1 → XP_030107954.1  WAP four-disulfide core domain protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14AE4
    Conserved Domains (1) summary
    pfam00095
    Location:23 → 58
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14AE4.1 GenPept UniProtKB/Swiss-Prot:Q14AE4

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