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Krt33a keratin 33A [ Mus musculus (house mouse) ]

Gene ID: 71888, updated on 2-Nov-2024

Summary

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Official Symbol
Krt33aprovided by MGI
Official Full Name
keratin 33Aprovided by MGI
Primary source
MGI:MGI:1919138
See related
Ensembl:ENSMUSG00000035592 AllianceGenome:MGI:1919138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310015J09Rik
Summary
Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Orthologous to human KRT31 (keratin 31); KRT33A (keratin 33A); and KRT34 (keratin 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Krt33a in Genome Data Viewer
Location:
11 D; 11 63.35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99902025..99907038, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100011199..100016212, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin associated protein 16-1 Neighboring gene keratin associated protein 17-1 Neighboring gene STARR-seq mESC enhancer starr_30710 Neighboring gene keratin 33B Neighboring gene keratin 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Fleger-Weckmann A, et al. Matrix Biol, 2016 Dec. PMID 27234308
  2. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
  3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type I cuticular Ha3-I
Names
K33A
hair keratin, type I Ha3-I
ortholog of keratin, hair, acidic, 3A KRTHA3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027983.3 → NP_082259.2  keratin, type I cuticular Ha3-I

    See identical proteins and their annotated locations for NP_082259.2

    Status: VALIDATED

    Source sequence(s)
    AK037251
    Consensus CDS
    CCDS25403.1
    UniProtKB/Swiss-Prot
    Q8K0Y2, Q9D7C4
    Related
    ENSMUSP00000018399.3, ENSMUST00000018399.3
    Conserved Domains (2) summary
    COG3352
    Location:252 → 363
    FlaC; Archaellum component FlaC [Cell motility]
    pfam00038
    Location:55 → 366
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99902025..99907038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0Y2.1 GenPept UniProtKB/Swiss-Prot:Q8K0Y2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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