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Gpc2 glypican 2 cerebroglycan [ Mus musculus (house mouse) ]

Gene ID: 71951, updated on 28-Oct-2024

Summary

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Official Symbol
Gpc2provided by MGI
Official Full Name
glypican 2 cerebroglycanprovided by MGI
Primary source
MGI:MGI:1919201
See related
Ensembl:ENSMUSG00000029510 AllianceGenome:MGI:1919201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410016G05Rik
Summary
Predicted to be involved in several processes, including positive regulation of neuron projection development; regulation of protein localization to membrane; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface and synapse. Is expressed in several structures, including branchial arch; lower jaw; nervous system; reproductive system; and sensory organ. Orthologous to human GPC2 (glypican 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in CNS E14 (RPKM 130.8), whole brain E14.5 (RPKM 125.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Gpc2 in Genome Data Viewer
Location:
5 G2; 5 77.0 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138271918..138278288, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138273657..138280026, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330418K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4800 Neighboring gene trafficking protein particle complex 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STARR-positive B cell enhancer ABC_E3630 Neighboring gene STAG3 cohesin complex component Neighboring gene poliovirus receptor related immunoglobulin domain containing Neighboring gene poliovirus receptor related immunoglobulin domain containing, pseudogene Neighboring gene glutamatic-oxaloacetic transaminase 2, mitochondrial, pseudogene 1 Neighboring gene predicted gene 10874

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis. Lugert S, et al. Sci Rep, 2017 Apr 25. PMID 28440309, Free PMC Article
  2. Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Jen YH, et al. Neural Dev, 2009 Sep 4. PMID 19732411, Free PMC Article
  3. Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain. Luxardi G, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17107664
  4. Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Ford-Perriss M, et al. Dev Dyn, 2003 Jun. PMID 12761845
  5. Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis. Wishart TFL, et al. Cells, 2023 May 11. PMID 37408198, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC90563

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glypican-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417777.1 → NP_001404706.1  glypican-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159257

  2. NM_172412.3 → NP_766000.1  glypican-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766000.1

    Status: VALIDATED

    Source sequence(s)
    AC159257
    Consensus CDS
    CCDS19799.1
    UniProtKB/Swiss-Prot
    Q8BKV1
    UniProtKB/TrEMBL
    F8WHY9
    Related
    ENSMUSP00000124459.2, ENSMUST00000161827.8
    Conserved Domains (1) summary
    pfam01153
    Location:20 → 559
    Glypican; Glypican

RNA

  1. NR_184575.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159257
    Related
    ENSMUST00000161984.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138271918..138278288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165503.1 → XP_036021396.1  glypican-2 isoform X2

    Conserved Domains (1) summary
    pfam01153
    Location:1 → 305
    Glypican

  2. XM_006504624.3 → XP_006504687.1  glypican-2 isoform X2

    Related
    ENSMUST00000159689.8
    Conserved Domains (1) summary
    pfam01153
    Location:1 → 305
    Glypican

  3. XM_036165502.1 → XP_036021395.1  glypican-2 isoform X1

    Conserved Domains (1) summary
    pfam01153
    Location:2 → 424
    Glypican

  4. XM_030254816.2 → XP_030110676.1  glypican-2 isoform X3

    Conserved Domains (1) summary
    pfam01153
    Location:9 → 325
    Glypican
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKV1.1 GenPept UniProtKB/Swiss-Prot:Q8BKV1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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