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Ints11 integrator complex subunit 11 [ Mus musculus (house mouse) ]

Gene ID: 71957, updated on 2-Nov-2024

Summary

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Official Symbol
Ints11provided by MGI
Official Full Name
integrator complex subunit 11provided by MGI
Primary source
MGI:MGI:1919207
See related
Ensembl:ENSMUSG00000029034 AllianceGenome:MGI:1919207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpsf3l; 2410006F12Rik
Summary
Predicted to enable RNA endonuclease activity. Predicted to be involved in snRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 20.9), CNS E14 (RPKM 18.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ints11 in Genome Data Viewer
Location:
4 E2; 4 87.66 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155954006..155973561)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155869547..155889103)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene pseudouridylate synthase-like 1 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel, nonvoltage-gated 1, delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Constraint and divergence of global gene expression in the mammalian embryo. Spies N, et al. Elife, 2015 Apr 14. PMID 25871848, Free PMC Article
  2. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
  3. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Vervoort SJ, et al. Cell, 2021 Jun 10. PMID 34004147, Free PMC Article
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator complex subunit 11
Names
CPSF3-like protein
cleavage and polyadenylation specific factor 3-like
cleavage and polyadenylation-specific factor 3-like protein
int11
NP_082296.1
XP_036020345.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028020.4 → NP_082296.1  integrator complex subunit 11

    See identical proteins and their annotated locations for NP_082296.1

    Status: VALIDATED

    Source sequence(s)
    AL670236
    Consensus CDS
    CCDS19048.1
    UniProtKB/Swiss-Prot
    Q3TJ34, Q3U7B0, Q91X99, Q922F0, Q9CWS4
    UniProtKB/TrEMBL
    A8Y5J3
    Related
    ENSMUSP00000030901.3, ENSMUST00000030901.9
    Conserved Domains (2) summary
    COG1236
    Location:4 → 444
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    cd16291
    Location:6 → 204
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

RNA

  1. NR_185037.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670236

  2. NR_185038.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670236

  3. NR_185039.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670236

  4. NR_185040.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670236

  5. NR_185041.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670236

  6. NR_185042.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670236

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155954006..155973561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164452.1 → XP_036020345.1  integrator complex subunit 11 isoform X4

    Conserved Domains (1) summary
    COG1782
    Location:4 → 148
    COG1782; Predicted metal-dependent RNase, contains metallo-beta-lactamase and KH domains [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWS4.1 GenPept UniProtKB/Swiss-Prot:Q9CWS4

Gene LinkOut

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