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Rbpms2 RNA binding protein with multiple splicing 2 [ Mus musculus (house mouse) ]

Gene ID: 71973, updated on 2-Nov-2024

Summary

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Official Symbol
Rbpms2provided by MGI
Official Full Name
RNA binding protein with multiple splicing 2provided by MGI
Primary source
MGI:MGI:1919223
See related
Ensembl:ENSMUSG00000032387 AllianceGenome:MGI:1919223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2400008B06Rik
Summary
Predicted to enable mRNA binding activity and protein homodimerization activity. Predicted to be involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of BMP signaling pathway; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; retina; and trigeminal ganglion. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 74.7), adrenal adult (RPKM 48.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Rbpms2 in Genome Data Viewer
Location:
9 C; 9 35.43 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65536638..65567818)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65629356..65660536)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2898 Neighboring gene STARR-seq mESC enhancer starr_24463 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene predicted pseudogene 10144 Neighboring gene STARR-seq mESC enhancer starr_24464 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65469333-65469516 Neighboring gene STARR-seq mESC enhancer starr_24467 Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene ATP synthase subunit f, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway. Zhou C, et al. Reprod Biomed Online, 2023 Oct. PMID 37573751
  2. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
  3. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway.
    Title: Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA-binding protein with multiple splicing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028030.3 → NP_082306.2  RNA-binding protein with multiple splicing 2

    See identical proteins and their annotated locations for NP_082306.2

    Status: PROVISIONAL

    Source sequence(s)
    AC121979
    Consensus CDS
    CCDS23296.1
    UniProtKB/Swiss-Prot
    Q8VC52
    UniProtKB/TrEMBL
    Q9CWY6
    Related
    ENSMUSP00000057600.9, ENSMUST00000055844.10
    Conserved Domains (1) summary
    cd12683
    Location:24 → 99
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65536638..65567818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511456.4 → XP_006511519.1  RNA-binding protein with multiple splicing 2 isoform X1

    See identical proteins and their annotated locations for XP_006511519.1

    UniProtKB/Swiss-Prot
    Q8VC52
    UniProtKB/TrEMBL
    Q9CWY6
    Conserved Domains (1) summary
    cd12683
    Location:24 → 99
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  2. XM_006511455.2 → XP_006511518.1  RNA-binding protein with multiple splicing 2 isoform X1

    See identical proteins and their annotated locations for XP_006511518.1

    UniProtKB/Swiss-Prot
    Q8VC52
    UniProtKB/TrEMBL
    Q9CWY6
    Related
    ENSMUSP00000131076.2, ENSMUST00000169003.8
    Conserved Domains (1) summary
    cd12683
    Location:24 → 99
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  3. XM_006511457.3 → XP_006511520.1  RNA-binding protein with multiple splicing 2 isoform X1

    See identical proteins and their annotated locations for XP_006511520.1

    UniProtKB/Swiss-Prot
    Q8VC52
    UniProtKB/TrEMBL
    Q9CWY6
    Conserved Domains (1) summary
    cd12683
    Location:24 → 99
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  4. XM_006511458.4 → XP_006511521.1  RNA-binding protein with multiple splicing 2 isoform X1

    See identical proteins and their annotated locations for XP_006511521.1

    UniProtKB/Swiss-Prot
    Q8VC52
    UniProtKB/TrEMBL
    Q9CWY6
    Conserved Domains (1) summary
    cd12683
    Location:24 → 99
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC52.1 GenPept UniProtKB/Swiss-Prot:Q8VC52

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