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TH tyrosine hydroxylase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 721137, updated on 17-Aug-2024

Summary

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Official Symbol
THprovided by VGNC
Official Full Name
tyrosine hydroxylaseprovided by VGNC
Primary source
VGNC:VGNC:78342
See related
Ensembl:ENSMMUG00000003912
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (2224320..2232217, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (1986614..1992686, complement)

Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 2 Neighboring gene insulin Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene chromosome 14 C11orf21 homolog Neighboring gene tetraspanin 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tyrosine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dopamine biosynthetic process from tyrosine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine 3-monooxygenase
XP_028688883.1
XP_028688884.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041767.1 Reference Mmul_10 Primary Assembly

    Range
    2224320..2232217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028833050.1 → XP_028688883.1  tyrosine 3-monooxygenase isoform X1

    UniProtKB/TrEMBL
    F6ZV38
    Related
    ENSMMUP00000005218.4, ENSMMUT00000005543.4
    Conserved Domains (3) summary
    cd04930
    Location:42 → 163
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    pfam00351
    Location:168 → 498
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:2 → 26
    TOH_N; Tyrosine hydroxylase N terminal

  2. XM_028833051.1 → XP_028688884.1  tyrosine 3-monooxygenase isoform X2

    Conserved Domains (3) summary
    cd04930
    Location:70 → 191
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    pfam00351
    Location:196 → 526
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:2 → 26
    TOH_N; Tyrosine hydroxylase N terminal
Nucleotide Protein
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