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Cep89 centrosomal protein 89 [ Mus musculus (house mouse) ]

Gene ID: 72140, updated on 28-Oct-2024

Summary

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Official Symbol
Cep89provided by MGI
Official Full Name
centrosomal protein 89provided by MGI
Primary source
MGI:MGI:1919390
See related
Ensembl:ENSMUSG00000023072 AllianceGenome:MGI:1919390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc123; 2610507L03Rik
Summary
Predicted to be involved in cilium assembly and mitochondrion organization. Located in centriole and motile cilium. Part of ciliary transition fiber. Is expressed in cerebral cortex. Orthologous to human CEP89 (centrosomal protein 89). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 20.4), CNS E11.5 (RPKM 8.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cep89 in Genome Data Viewer
Location:
7 B2; 7 21.37 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35096425..35139255)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35396999..35439830)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene predicted gene, 51476 Neighboring gene STARR-positive B cell enhancer ABC_E699 Neighboring gene Fanconi anemia core complex associated protein 24 Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Primary ciliogenesis requires the distal appendage component Cep123. Sillibourne JE, et al. Biol Open, 2013 Jun 15. PMID 23789104, Free PMC Article
  2. Centrosome anchoring regulates progenitor properties and cortical formation. Shao W, et al. Nature, 2020 Apr. PMID 32238932, Free PMC Article
  3. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Ye X, et al. Proc Natl Acad Sci U S A, 2014 Feb 11. PMID 24469809, Free PMC Article
  4. Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. Ding W, et al. J Neurosci, 2019 Mar 13. PMID 30626697, Free PMC Article
  5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ciliary transition fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ciliary transition fiber IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 89 kDa
Names
coiled-coil domain containing 123
coiled-coil domain-containing protein 123, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028120.3 → NP_082396.1  centrosomal protein of 89 kDa

    See identical proteins and their annotated locations for NP_082396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding variant.
    Source sequence(s)
    AC151535, AK012067, AK029107
    Consensus CDS
    CCDS39911.1
    UniProtKB/Swiss-Prot
    Q8C127, Q9CZX2
    Related
    ENSMUSP00000078383.6, ENSMUST00000079414.12
    Conserved Domains (1) summary
    cl15415
    Location:458 → 540
    Sec1; Sec1 family

RNA

  1. NR_153799.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC151535, AC154126

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    35096425..35139255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153454.1 → XP_036009347.1  centrosomal protein of 89 kDa isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:7 → 243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_004934188.1 RNA Sequence

  2. XR_004934187.1 RNA Sequence

  3. XR_004934189.1 RNA Sequence

    Related
    ENSMUST00000141704.8

  4. XR_391104.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZX2.1 GenPept UniProtKB/Swiss-Prot:Q9CZX2

Gene LinkOut

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