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Zfp661 zinc finger protein 661 [ Mus musculus (house mouse) ]

Gene ID: 72180, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp661provided by MGI
Official Full Name
zinc finger protein 661provided by MGI
Primary source
MGI:MGI:1919430
See related
Ensembl:ENSMUSG00000034800 AllianceGenome:MGI:1919430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A1-5; Znf2; 2810405K07Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF2 (zinc finger protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.6), CNS E14 (RPKM 1.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp661 in Genome Data Viewer
Location:
2 F1; 2 62.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127416537..127429014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127574617..127587094, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35478 Neighboring gene prominin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:127385126-127385426 Neighboring gene predicted gene 14229 Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene STARR-seq mESC enhancer starr_05627 Neighboring gene STARR-seq mESC enhancer starr_05628 Neighboring gene myelin and lymphocyte protein, T cell differentiation protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article
  2. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 2
Names
zfp-661
zinc finger protein 2 (A1-5)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111029.1 → NP_001104499.1  zinc finger protein 2 isoform a

    See identical proteins and their annotated locations for NP_001104499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK033122, AL731831
    Consensus CDS
    CCDS16705.1
    UniProtKB/Swiss-Prot
    Q7TPW3, Q8BIQ3
    Related
    ENSMUSP00000076637.6, ENSMUST00000077422.12
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:153 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001355622.1 → NP_001342551.1  zinc finger protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK134651, AL731831
    Consensus CDS
    CCDS16705.1
    UniProtKB/Swiss-Prot
    Q7TPW3, Q8BIQ3
    Related
    ENSMUSP00000105995.2, ENSMUST00000110366.8
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:153 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001355623.1 → NP_001342552.1  zinc finger protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL731831
    Conserved Domains (3) summary
    smart00349
    Location:2 → 52
    KRAB; krueppel associated box
    COG5048
    Location:131 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_028141.3 → NP_082417.3  zinc finger protein 2 isoform a

    See identical proteins and their annotated locations for NP_082417.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731831, BC052876
    Consensus CDS
    CCDS16705.1
    UniProtKB/Swiss-Prot
    Q7TPW3, Q8BIQ3
    Related
    ENSMUSP00000105997.3, ENSMUST00000110368.9
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:153 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127416537..127429014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252108.2 → XP_030107968.1  zinc finger protein 2 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:44 → 94
    KRAB; krueppel associated box
    COG5048
    Location:173 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036162588.1 → XP_036018481.1  zinc finger protein 2 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:113 → 377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:12 → 34
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_011239788.4 → XP_011238090.1  zinc finger protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011238090.1

    UniProtKB/Swiss-Prot
    Q7TPW3, Q8BIQ3
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:153 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_011239787.4 → XP_011238089.1  zinc finger protein 2 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:51 → 101
    KRAB; krueppel associated box
    COG5048
    Location:180 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036162589.1 → XP_036018482.1  zinc finger protein 2 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:113 → 377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:12 → 34
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. XM_030252107.2 → XP_030107967.1  zinc finger protein 2 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:51 → 101
    KRAB; krueppel associated box
    COG5048
    Location:180 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030252111.1 → XP_030107971.1  zinc finger protein 2 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:113 → 377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:12 → 34
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  8. XM_036162590.1 → XP_036018483.1  zinc finger protein 2 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:97 → 246
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:73 → 93
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:29 → 54
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIQ3.1 GenPept UniProtKB/Swiss-Prot:Q8BIQ3

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