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Dbndd1 dysbindin domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 72185, updated on 28-Oct-2024

Summary

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Official Symbol
Dbndd1provided by MGI
Official Full Name
dysbindin domain containing 1provided by MGI
Primary source
MGI:MGI:1919435
See related
Ensembl:ENSMUSG00000031970 AllianceGenome:MGI:1919435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd590e; 2810427I04Rik
Summary
Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human DBNDD1 (dysbindin domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 13.4), whole brain E14.5 (RPKM 11.1) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Dbndd1 in Genome Data Viewer
Location:
8 E1; 8 72.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124231744..124245535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123504718..123518277, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39275 Neighboring gene AFG3-like AAA ATPase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6700 Neighboring gene growth arrest specific 8 Neighboring gene nuclear encoded rRNA 5S 100

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Nunome M, et al. Mol Ecol, 2010 Jun 1. PMID 20465587
  2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dysbindin domain-containing protein 1
Names
dysbindin (dystrobrevin binding protein 1) domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170975.3 → NP_001164446.3  dysbindin domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC158362
    Consensus CDS
    CCDS52702.2
    Related
    ENSMUSP00000135216.3, ENSMUST00000177240.9
    Conserved Domains (1) summary
    pfam04440
    Location:16 → 105
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  2. NM_001170976.2 → NP_001164447.3  dysbindin domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central coding region and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC158362
    Consensus CDS
    CCDS52701.2
    UniProtKB/TrEMBL
    H3BIX2
    Related
    ENSMUSP00000134757.3, ENSMUST00000176286.9

  3. NM_001395625.1 → NP_001382554.1  dysbindin domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158362
    Conserved Domains (1) summary
    pfam04440
    Location:46 → 182
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  4. NM_001395626.1 → NP_001382555.1  dysbindin domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158362
    Conserved Domains (1) summary
    pfam04440
    Location:1 → 120
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  5. NM_028146.5 → NP_082422.4  dysbindin domain-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). An in-frame AUG is located 29 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is too close to the presumed transcription start site.
    Source sequence(s)
    AC158362
    Consensus CDS
    CCDS22761.3
    UniProtKB/Swiss-Prot
    Q80XJ9, Q8BMU4, Q9CZ00
    UniProtKB/TrEMBL
    H3BKU0
    Related
    ENSMUSP00000135524.3, ENSMUST00000176155.3
    Conserved Domains (1) summary
    pfam04440
    Location:16 → 152
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124231744..124245535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248510.3 → XP_011246812.1  dysbindin domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam04440
    Location:39 → 175
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  2. XM_011248509.4 → XP_011246811.1  dysbindin domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    PRK13108
    Location:4 → 93
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam04440
    Location:56 → 192
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ00.1 GenPept UniProtKB/Swiss-Prot:Q9CZ00

Gene LinkOut

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