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Asb6 ankyrin repeat and SOCS box-containing 6 [ Mus musculus (house mouse) ]

Gene ID: 72323, updated on 28-Oct-2024

Summary

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Official Symbol
Asb6provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 6provided by MGI
Primary source
MGI:MGI:1919573
See related
Ensembl:ENSMUSG00000039483 AllianceGenome:MGI:1919573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510004M11Rik
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in limb and limb mesenchyme. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 26.4), adrenal adult (RPKM 25.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Asb6 in Genome Data Viewer
Location:
2 B; 2 21.74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30713109..30718312, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30823097..30828300, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001O22 gene Neighboring gene predicted gene, 54110 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10091 Neighboring gene paired related homeobox 2 Neighboring gene prostaglandin E synthase Neighboring gene predicted gene, 52550

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. Wilcox A, et al. J Biol Chem, 2004 Sep 10. PMID 15231829
  2. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
  3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 6
Names
ASB-6
ankyrin repeat and SOCS box-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133346.2 → NP_579924.1  ankyrin repeat and SOCS box protein 6

    See identical proteins and their annotated locations for NP_579924.1

    Status: VALIDATED

    Source sequence(s)
    AK049312, BY336511, CD776641
    Consensus CDS
    CCDS38096.1
    UniProtKB/Swiss-Prot
    Q8VEC6, Q91ZU1
    UniProtKB/TrEMBL
    Q6BCN6
    Related
    ENSMUSP00000043462.4, ENSMUST00000041726.4
    Conserved Domains (4) summary
    cd00204
    Location:102 → 212
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:368 → 411
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    pfam12796
    Location:71 → 166
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:103 → 131
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30713109..30718312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZU1.1 GenPept UniProtKB/Swiss-Prot:Q91ZU1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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