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Prr5l proline rich 5 like [ Mus musculus (house mouse) ]

Gene ID: 72446, updated on 5-Mar-2024

Summary

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Official Symbol
Prr5lprovided by MGI
Official Full Name
proline rich 5 likeprovided by MGI
Primary source
MGI:MGI:1919696
See related
Ensembl:ENSMUSG00000032841 AllianceGenome:MGI:1919696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Protor2; Protor-2; 2600010E01Rik; 4833411O04Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in TORC2 signaling and regulation of fibroblast migration. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase signaling and positive regulation of protein phosphorylation. Located in mitochondrion. Is expressed in cranium; genitourinary system; jaw; and limb. Orthologous to human PRR5L (proline rich 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 4.9), cerebellum adult (RPKM 2.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Prr5l in Genome Data Viewer
Location:
2 E2; 2 53.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101543455..101713428, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101713110..101883052, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5948 Neighboring gene predicted gene, 34041 Neighboring gene TNF receptor-associated factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene STARR-seq mESC enhancer starr_05238 Neighboring gene COMM domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101819193-101819405 Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101831937-101832164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101833086-101833410 Neighboring gene predicted gene, 39888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Gan X, et al. Nat Cell Biol, 2012 May 20. PMID 22609986, Free PMC Article
  2. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Pearce LR, et al. Biochem J, 2011 May 15. PMID 21413931
  3. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Hecht J, et al. Gene Expr Patterns, 2007 Jan. PMID 16829211
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
    Title: PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
proline-rich protein 5-like
Names
protein observed with Rictor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083810.2 → NP_001077279.1  proline-rich protein 5-like

    See identical proteins and their annotated locations for NP_001077279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL929571, BB166811, BC048394, BY737227, CF171561
    Consensus CDS
    CCDS38186.1
    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Related
    ENSMUSP00000130152.2, ENSMUST00000171088.8
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  2. NM_001110849.1 → NP_001104319.1  proline-rich protein 5-like

    See identical proteins and their annotated locations for NP_001104319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL929571, BB166811, BC048394, CJ073028
    Consensus CDS
    CCDS38186.1
    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Related
    ENSMUSP00000127530.2, ENSMUST00000163762.8
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  3. NM_001355625.1 → NP_001342554.1  proline-rich protein 5-like

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL929534, AL929571
    Consensus CDS
    CCDS38186.1
    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  4. NM_175181.5 → NP_780390.3  proline-rich protein 5-like

    See identical proteins and their annotated locations for NP_780390.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL929571, BB166811, BC048394, BY737227
    Consensus CDS
    CCDS38186.1
    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Related
    ENSMUSP00000042167.8, ENSMUST00000043845.14
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    101543455..101713428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162597.1 → XP_036018490.1  proline-rich protein 5-like isoform X2

    Conserved Domains (1) summary
    pfam08539
    Location:146 → 265
    HbrB; HbrB-like

  2. XM_036162598.1 → XP_036018491.1  proline-rich protein 5-like isoform X3

    Conserved Domains (1) summary
    pfam08539
    Location:123 → 242
    HbrB; HbrB-like

  3. XM_036162596.1 → XP_036018489.1  proline-rich protein 5-like isoform X2

    Conserved Domains (1) summary
    pfam08539
    Location:146 → 265
    HbrB; HbrB-like

  4. XM_036162599.1 → XP_036018492.1  proline-rich protein 5-like isoform X5

    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  5. XM_017319278.3 → XP_017174767.1  proline-rich protein 5-like isoform X4

    Conserved Domains (1) summary
    pfam08539
    Location:110 → 229
    HbrB; HbrB-like

  6. XM_036162600.1 → XP_036018493.1  proline-rich protein 5-like isoform X5

    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  7. XM_006500236.5 → XP_006500299.2  proline-rich protein 5-like isoform X1

    Conserved Domains (1) summary
    pfam08539
    Location:95 → 214
    HbrB; HbrB-like

  8. XM_006500241.5 → XP_006500304.1  proline-rich protein 5-like isoform X5

    See identical proteins and their annotated locations for XP_006500304.1

    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  9. XM_006500240.5 → XP_006500303.1  proline-rich protein 5-like isoform X5

    See identical proteins and their annotated locations for XP_006500303.1

    UniProtKB/Swiss-Prot
    A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AVJ5.1 GenPept UniProtKB/Swiss-Prot:A2AVJ5

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