Prr5l proline rich 5 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prr5lprovided by MGI
Official Full Name: proline rich 5 likeprovided by MGI
Primary source: MGI:MGI:1919696
See related: Ensembl:ENSMUSG00000032841 AllianceGenome:MGI:1919696
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Protor2; Protor-2; 2600010E01Rik; 4833411O04Rik
Summary: Predicted to enable ubiquitin protein ligase binding activity. Involved in TORC2 signaling and regulation of fibroblast migration. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Located in mitochondrion. Is expressed in cranium; genitourinary system; jaw; and limb. Orthologous to human PRR5L (proline rich 5 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 4.9), cerebellum adult (RPKM 2.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 53.93 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (101543455..101713428, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (101713110..101883052, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
Title: PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

2600010E01Rik (e-PCR), detects polymorphism
- UniSTS:498417

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC2 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: proline-rich protein 5-like

Names: protein observed with Rictor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083810.2 → NP_001077279.1 proline-rich protein 5-like

See identical proteins and their annotated locations for NP_001077279.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.

Source sequence(s)

AL929571, BB166811, BC048394, BY737227, CF171561

Consensus CDS

CCDS38186.1

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Related

ENSMUSP00000130152.2, ENSMUST00000171088.8

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
NM_001110849.1 → NP_001104319.1 proline-rich protein 5-like

See identical proteins and their annotated locations for NP_001104319.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AL929571, BB166811, BC048394, CJ073028

Consensus CDS

CCDS38186.1

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Related

ENSMUSP00000127530.2, ENSMUST00000163762.8

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
NM_001355625.1 → NP_001342554.1 proline-rich protein 5-like

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AL929534, AL929571

Consensus CDS

CCDS38186.1

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
NM_175181.5 → NP_780390.3 proline-rich protein 5-like

See identical proteins and their annotated locations for NP_780390.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AL929571, BB166811, BC048394, BY737227

Consensus CDS

CCDS38186.1

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Related

ENSMUSP00000042167.8, ENSMUST00000043845.14

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

101543455..101713428 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162597.1 → XP_036018490.1 proline-rich protein 5-like isoform X2

Conserved Domains (1) summary

pfam08539
Location:146 → 265

HbrB; HbrB-like
XM_036162598.1 → XP_036018491.1 proline-rich protein 5-like isoform X3

Conserved Domains (1) summary

pfam08539
Location:123 → 242

HbrB; HbrB-like
XM_036162596.1 → XP_036018489.1 proline-rich protein 5-like isoform X2

Conserved Domains (1) summary

pfam08539
Location:146 → 265

HbrB; HbrB-like
XM_036162599.1 → XP_036018492.1 proline-rich protein 5-like isoform X5

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
XM_017319278.3 → XP_017174767.1 proline-rich protein 5-like isoform X4

Conserved Domains (1) summary

pfam08539
Location:110 → 229

HbrB; HbrB-like
XM_036162600.1 → XP_036018493.1 proline-rich protein 5-like isoform X5

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
XM_006500236.5 → XP_006500299.2 proline-rich protein 5-like isoform X1

Conserved Domains (1) summary

pfam08539
Location:95 → 214

HbrB; HbrB-like
XM_006500241.5 → XP_006500304.1 proline-rich protein 5-like isoform X5

See identical proteins and their annotated locations for XP_006500304.1

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
XM_006500240.5 → XP_006500303.1 proline-rich protein 5-like isoform X5

See identical proteins and their annotated locations for XP_006500303.1

UniProtKB/Swiss-Prot

A2AVJ5, B7ZWM2, Q80Y78, Q8BIT0

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like