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Bltp2 bridge-like lipid transfer protein family member 2 [ Mus musculus (house mouse) ]

Gene ID: 72503, updated on 2-Nov-2024

Summary

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Official Symbol
Bltp2provided by MGI
Official Full Name
bridge-like lipid transfer protein family member 2provided by MGI
Primary source
MGI:MGI:1919753
See related
Ensembl:ENSMUSG00000010277 AllianceGenome:MGI:1919753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E1; mKIAA0100; D11Bhm178e; D11Bhm179e; 2610507B11Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Is expressed in several structures, including adrenal medulla; glans of male genital tubercle; gut; nasal cavity epithelium; and nervous system. Orthologous to human BLTP2 (bridge-like lipid transfer protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 45.9), kidney adult (RPKM 37.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bltp2 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78152476..78181451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78261650..78290625)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78029402-78029555 Neighboring gene SPT6, histone chaperone and transcription elongation factor Neighboring gene STARR-seq mESC enhancer starr_30092 Neighboring gene small nuclear ribonucleoprotein N pseudogene Neighboring gene stromal cell derived factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene predicted gene 3948 Neighboring gene ribosomal protein S6 kinase related Neighboring gene sperm associated antigen 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Nehls M, et al. Mamm Genome, 1995 May. PMID 7626882
  2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0100

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bridge-like lipid transfer protein family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002004.2 → NP_001002004.2  bridge-like lipid transfer protein family member 2 precursor

    See identical proteins and their annotated locations for NP_001002004.2

    Status: VALIDATED

    Source sequence(s)
    AK029280, AK149719, AK150829, BC075633
    Consensus CDS
    CCDS25097.1
    UniProtKB/Swiss-Prot
    Q3UE65, Q5SYL3, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8
    Related
    ENSMUSP00000010421.7, ENSMUST00000010421.7
    Conserved Domains (3) summary
    pfam10344
    Location:26 → 674
    Fmp27; Mitochondrial protein from FMP27
    pfam10347
    Location:1028 → 1160
    Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
    pfam10351
    Location:1703 → 2176
    Apt1; Golgi-body localization protein domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78152476..78181451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534313.3 → XP_006534376.1  bridge-like lipid transfer protein family member 2 isoform X2

    Conserved Domains (2) summary
    pfam10344
    Location:26 → 674
    Fmp27; Mitochondrial protein from FMP27
    pfam10347
    Location:1028 → 1160
    Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain

  2. XM_006534312.3 → XP_006534375.1  bridge-like lipid transfer protein family member 2 isoform X1

    Conserved Domains (3) summary
    pfam10344
    Location:1 → 531
    Fmp27; Mitochondrial protein from FMP27
    pfam10347
    Location:885 → 1017
    Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
    pfam10351
    Location:1560 → 2033
    Apt1; Golgi-body localization protein domain

  3. XM_030246365.2 → XP_030102225.1  bridge-like lipid transfer protein family member 2 isoform X1

    Conserved Domains (3) summary
    pfam10344
    Location:1 → 531
    Fmp27; Mitochondrial protein from FMP27
    pfam10347
    Location:885 → 1017
    Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
    pfam10351
    Location:1560 → 2033
    Apt1; Golgi-body localization protein domain

RNA

  1. XR_001780057.3 RNA Sequence

  2. XR_001780058.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SYL3.1 GenPept UniProtKB/Swiss-Prot:Q5SYL3

Gene LinkOut

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