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Exosc6 exosome component 6 [ Mus musculus (house mouse) ]

Gene ID: 72544, updated on 2-Nov-2024

Summary

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Official Symbol
Exosc6provided by MGI
Official Full Name
exosome component 6provided by MGI
Primary source
MGI:MGI:1919794
See related
Ensembl:ENSMUSG00000109941 AllianceGenome:MGI:1919794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtr3; C76919; 2610510N21Rik
Summary
Predicted to enable RNA binding activity. Involved in isotype switching. Acts upstream of or within positive regulation of isotype switching. Predicted to be located in cytosol and nucleus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; gonad; liver; retina; and submandibular gland primordium. Orthologous to human EXOSC6 (exosome component 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Exosc6 in Genome Data Viewer
Location:
8 E1; 8 57.92 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111782971..111784296)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111056339..111057664)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 19a Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d Neighboring gene STARR-positive B cell enhancer ABC_E566 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exosome complex components 1 and 2 are vital for early mammalian development. Srinivasan S, et al. Gene Expr Patterns, 2024 Mar. PMID 37940010,
  2. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Basu U, et al. Cell, 2011 Feb 4. PMID 21255825, Free PMC Article
  3. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Chen CY, et al. Cell, 2001 Nov 16. PMID 11719186
  4. Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Ulmke PA, et al. Development, 2021 Feb 8. PMID 33462115, Free PMC Article
  5. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151362

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA deamination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA deamination ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isotype switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of isotype switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exosome complex component MTR3
Names
Mtr3 (mRNA transport regulator 3)-homolog
exosome complex exonuclease MTR3
NP_082550.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028274.4 → NP_082550.1  exosome complex component MTR3

    See identical proteins and their annotated locations for NP_082550.1

    Status: VALIDATED

    Source sequence(s)
    BC116985, BM941848
    Consensus CDS
    CCDS85611.1
    UniProtKB/Swiss-Prot
    Q8BTW3, Q9CSR7
    Related
    ENSMUSP00000147696.2, ENSMUST00000210390.2
    Conserved Domains (2) summary
    cd11371
    Location:36 → 261
    RNase_PH_MTR3; MTR3 subunit of eukaryotic exosome
    COG0689
    Location:28 → 260
    Rph; Ribonuclease PH [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111782971..111784296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTW3.1 GenPept UniProtKB/Swiss-Prot:Q8BTW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous