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Hsdl1 hydroxysteroid dehydrogenase like 1 [ Mus musculus (house mouse) ]

Gene ID: 72552, updated on 28-Oct-2024

Summary

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Official Symbol
Hsdl1provided by MGI
Official Full Name
hydroxysteroid dehydrogenase like 1provided by MGI
Primary source
MGI:MGI:1919802
See related
Ensembl:ENSMUSG00000034189 AllianceGenome:MGI:1919802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700067E09Rik
Summary
Located in mitochondrion. Is expressed in central nervous system; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 41.1), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hsdl1 in Genome Data Viewer
Location:
8 E1; 8 67.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120288717..120301930, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119561978..119575214, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 8 Neighboring gene STARR-seq mESC enhancer starr_22850 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene STARR-seq mESC enhancer starr_22853 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122082621-122082922 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087691-122087878 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087910-122088232 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122093859-122094132 Neighboring gene STARR-seq mESC enhancer starr_22854 Neighboring gene dynein, axonemal assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_22855 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  2. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
  3. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
NOT enables steroid dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive hydroxysteroid dehydrogenase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379016.1 → NP_001365945.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AC104882
    UniProtKB/Swiss-Prot
    Q3U839, Q8BTX9
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

  2. NM_001379017.1 → NP_001365946.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC104882
    UniProtKB/Swiss-Prot
    Q3U839, Q8BTX9
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

  3. NM_001379018.1 → NP_001365947.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104882
    UniProtKB/TrEMBL
    A0A1D5RLG0
    Conserved Domains (1) summary
    cd05356
    Location:46 → 288
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

  4. NM_175185.5 → NP_780394.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_780394.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC104882
    Consensus CDS
    CCDS22708.1
    UniProtKB/Swiss-Prot
    Q3U839, Q8BTX9
    Related
    ENSMUSP00000044371.5, ENSMUST00000036049.6
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

RNA

  1. NR_166413.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104882

  2. NR_166414.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104882

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120288717..120301930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531397.5 → XP_006531460.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006531460.1

    UniProtKB/Swiss-Prot
    Q3U839, Q8BTX9
    Conserved Domains (1) summary
    cd05356
    Location:67 → 309
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

  2. XM_036154310.1 → XP_036010203.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLG0
    Related
    ENSMUSP00000148352.2, ENSMUST00000212517.2
    Conserved Domains (1) summary
    cd05356
    Location:46 → 288
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

RNA

  1. XR_003947344.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTX9.1 GenPept UniProtKB/Swiss-Prot:Q8BTX9

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