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Pan3 PAN3 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

Gene ID: 72587, updated on 2-Nov-2024

Summary

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Official Symbol
Pan3provided by MGI
Official Full Name
PAN3 poly(A) specific ribonuclease subunitprovided by MGI
Primary source
MGI:MGI:1919837
See related
Ensembl:ENSMUSG00000029647 AllianceGenome:MGI:1919837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700050F09Rik; A430027N15Rik
Summary
Predicted to enable poly(A) binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Located in P-body. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 13.1), bladder adult (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pan3 in Genome Data Viewer
Location:
5 G3; 5 86.93 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147363018..147485310)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147426208..147548501)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14874 Neighboring gene STARR-seq mESC enhancer starr_14875 Neighboring gene STARR-positive B cell enhancer ABC_E8093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148238101-148238295 Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene predicted gene, 29793 Neighboring gene STARR-positive B cell enhancer ABC_E2773 Neighboring gene FMS-like tyrosine kinase 1 Neighboring gene predicted gene, 35383 Neighboring gene STARR-seq mESC enhancer starr_14879 Neighboring gene predicted gene, 35541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression. Zhang CL, et al. Lab Invest, 2021 Jan. PMID 32929177
  2. Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. Siddiqui N, et al. J Biol Chem, 2007 Aug 24. PMID 17595167
  3. Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. Zheng D, et al. J Cell Biol, 2008 Jul 14. PMID 18625844, Free PMC Article
  4. Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. Cai Y, et al. BMC Pulm Med, 2015 Jul 16. PMID 26178733, Free PMC Article
  5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.
    Title: CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.
  2. the poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein
    Title: Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99847, MGC102350

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cytoplasmic mRNA processing body assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex ISO
Inferred from Sequence Orthology
more info
  
part_of PAN complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PAN2-PAN3 deadenylation complex subunit Pan3
Names
PAB-dependent poly(A)-specific ribonuclease subunit 3
PAB1P-dependent poly(A)-specific ribonuclease
PAN3 polyA specific ribonuclease subunit homolog
Pabp-dependent poly(A) nuclease 3
Pabp1-dependent poly A-specific ribonuclease subunit Pan3
poly(A)-nuclease deadenylation complex subunit 3
NP_001346362.1
NP_001406711.1
NP_001406712.1
NP_001406713.1
NP_001406714.1
NP_001406715.1
NP_001406716.1
NP_082567.3
XP_006504932.1
XP_006504934.1
XP_006504935.1
XP_006504940.1
XP_006504941.1
XP_017176602.1
XP_030110691.1
XP_036021422.1
XP_036021423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359433.2 → NP_001346362.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441
    UniProtKB/TrEMBL
    H3BJH6
    Conserved Domains (2) summary
    pfam18101
    Location:430 → 567
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:181 → 349
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001419782.1 → NP_001406711.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441

  3. NM_001419783.1 → NP_001406712.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441
    UniProtKB/Swiss-Prot
    H3BKF3, Q3U5F2, Q640Q5, Q8CE75, Q9CZM6
    Related
    ENSMUSP00000135367.2, ENSMUST00000176600.8

  4. NM_001419784.1 → NP_001406713.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441

  5. NM_001419785.1 → NP_001406714.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441
    Related
    ENSMUSP00000134989.2, ENSMUST00000176753.8

  6. NM_001419786.1 → NP_001406715.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441

  7. NM_001419787.1 → NP_001406716.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441

  8. NM_028291.6 → NP_082567.3  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1

    See identical proteins and their annotated locations for NP_082567.3

    Status: VALIDATED

    Source sequence(s)
    AC131730, AC134441
    Consensus CDS
    CCDS39401.2
    UniProtKB/TrEMBL
    H3BJH6
    Related
    ENSMUSP00000031651.9, ENSMUST00000031651.15
    Conserved Domains (2) summary
    pfam00642
    Location:55 → 74
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:439 → 607
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147363018..147485310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504872.4 → XP_006504935.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X5

    Conserved Domains (3) summary
    pfam00642
    Location:55 → 74
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:742 → 852
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:493 → 661
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017321113.2 → XP_017176602.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X6

    Conserved Domains (3) summary
    pfam00642
    Location:55 → 74
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:703 → 840
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:571 → 694
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006504869.4 → XP_006504932.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X2

    Conserved Domains (3) summary
    pfam00642
    Location:55 → 74
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:741 → 878
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:492 → 660
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036165529.1 → XP_036021422.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X7

    UniProtKB/TrEMBL
    H3BJH6
    Conserved Domains (3) summary
    pfam00642
    Location:55 → 74
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:649 → 786
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:517 → 640
    PKc_like; Protein Kinases, catalytic domain

  5. XM_036165530.1 → XP_036021423.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

    UniProtKB/TrEMBL
    H3BJH6
    Conserved Domains (2) summary
    pfam18101
    Location:430 → 567
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:181 → 349
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006504878.4 → XP_006504941.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X11

    UniProtKB/TrEMBL
    H3BLB9
    Conserved Domains (2) summary
    pfam18101
    Location:408 → 545
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:159 → 327
    PKc_like; Protein Kinases, catalytic domain

  7. XM_006504871.4 → XP_006504934.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X4

    Conserved Domains (3) summary
    pfam00642
    Location:55 → 74
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:718 → 855
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:469 → 637
    PKc_like; Protein Kinases, catalytic domain

  8. XM_006504877.4 → XP_006504940.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X10

    UniProtKB/TrEMBL
    H3BLB9
    Related
    ENSMUSP00000135729.2, ENSMUST00000175807.8
    Conserved Domains (2) summary
    pfam18101
    Location:411 → 548
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:162 → 330
    PKc_like; Protein Kinases, catalytic domain

  9. XM_030254831.2 → XP_030110691.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

    UniProtKB/TrEMBL
    H3BJH6
    Conserved Domains (2) summary
    pfam18101
    Location:430 → 567
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:181 → 349
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004942572.1 RNA Sequence

  2. XR_004942573.1 RNA Sequence

  3. XR_004942570.1 RNA Sequence

  4. XR_004942571.1 RNA Sequence

  5. XR_004942574.1 RNA Sequence

  6. XR_004942575.1 RNA Sequence

    Related
    ENSMUST00000176596.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q640Q5.4 GenPept UniProtKB/Swiss-Prot:Q640Q5

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