U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anks3 ankyrin repeat and sterile alpha motif domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 72615, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Anks3provided by MGI
Official Full Name
ankyrin repeat and sterile alpha motif domain containing 3provided by MGI
Primary source
MGI:MGI:1919865
See related
Ensembl:ENSMUSG00000022515 AllianceGenome:MGI:1919865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1977; 2700067D09Rik
Summary
Located in cilium and cytoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 12.6), CNS E18 (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Anks3 in Genome Data Viewer
Location:
16 A1; 16 2.48 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4759290..4783362, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4941415..4965537, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mahogunin, ring finger 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:4938936-4939237 Neighboring gene predicted gene, 16861 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene predicted gene, 36681 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Metabolic Phenotyping of Anks3 Depletion in mIMCD-3 cells - a Putative Nephronophthisis Candidate. Schlimpert M, et al. Sci Rep, 2018 Jun 13. PMID 29899363, Free PMC Article
  2. Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3. Rothé B, et al. PLoS Biol, 2023 Sep. PMID 37733651, Free PMC Article
  3. ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. Delestré L, et al. PLoS One, 2015. PMID 26327442, Free PMC Article
  4. Anks3 alters the sub-cellular localization of the Nek7 kinase. Ramachandran H, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188091
  5. Anks3 interacts with nephronophthisis proteins and is required for normal renal development. Yakulov TA, et al. Kidney Int, 2015 Jun. PMID 25671767

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combined metabolomics successfully identified 155 metabolites; 48 metabolites were identified to be significantly altered by decreasing Ankyrin repeat and sterile alpha motif domain containing 3 protein (Anks3) levels.
    Title: Metabolic Phenotyping of Anks3 Depletion in mIMCD-3 cells - a Putative Nephronophthisis Candidate.
  2. ANKS3-ANKS6 direct interaction through their SAM domain.
    Title: ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice.
  3. Anks3 N-terminal ankyrin repeats, but not SAM domain required for Nek7 interaction.Nek7 increased Ser/Thr phosphorylation of Anks3 primarily within ankyrin domain.
    Title: Anks3 alters the sub-cellular localization of the Nek7 kinase.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ankyrin repeat and SAM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028301.5 → NP_082577.2  ankyrin repeat and SAM domain-containing protein 3

    See identical proteins and their annotated locations for NP_082577.2

    Status: VALIDATED

    Source sequence(s)
    AC163723, AC240849
    Consensus CDS
    CCDS27928.1
    UniProtKB/Swiss-Prot
    Q6ZPF6, Q80X46, Q9CZK6
    Related
    ENSMUSP00000023157.5, ENSMUST00000023157.6
    Conserved Domains (6) summary
    cd09519
    Location:423 → 486
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:422 → 481
    SAM; Sterile alpha motif
    cd00204
    Location:63 → 189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:106 → 199
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:512 → 608
    DUF4570; Domain of unknown function (DUF4570)
    sd00045
    Location:69 → 99
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4759290..4783362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522608.2 → XP_006522671.1  ankyrin repeat and SAM domain-containing protein 3 isoform X1

    Conserved Domains (5) summary
    cd09519
    Location:423 → 486
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    COG0666
    Location:29 → 192
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:69 → 99
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:169 → 221
    Ank_4; Ankyrin repeats (many copies)
    pfam15134
    Location:512 → 608
    DUF4570; Domain of unknown function (DUF4570)

  2. XM_006522610.3 → XP_006522673.1  ankyrin repeat and SAM domain-containing protein 3 isoform X3

    Conserved Domains (5) summary
    cd09519
    Location:423 → 486
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    COG0666
    Location:29 → 192
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:69 → 99
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:169 → 221
    Ank_4; Ankyrin repeats (many copies)
    pfam15134
    Location:512 → 608
    DUF4570; Domain of unknown function (DUF4570)

  3. XM_036160143.1 → XP_036016036.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

    Conserved Domains (3) summary
    cd09519
    Location:350 → 413
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:28 → 59
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:33 → 126
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_030249288.2 → XP_030105148.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

    Conserved Domains (5) summary
    cd09519
    Location:362 → 425
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    PLN03192
    Location:16 → 185
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:73 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 138
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:451 → 547
    DUF4570; Domain of unknown function (DUF4570)

  5. XM_036160146.1 → XP_036016039.1  ankyrin repeat and SAM domain-containing protein 3 isoform X14

    Conserved Domains (2) summary
    cd09519
    Location:250 → 313
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    cl39094
    Location:1 → 48
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_006522609.4 → XP_006522672.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

    Conserved Domains (5) summary
    cd09519
    Location:423 → 486
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    COG0666
    Location:29 → 192
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:69 → 99
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:169 → 221
    Ank_4; Ankyrin repeats (many copies)
    pfam15134
    Location:512 → 608
    DUF4570; Domain of unknown function (DUF4570)

  7. XM_030249290.2 → XP_030105150.1  ankyrin repeat and SAM domain-containing protein 3 isoform X9

    Conserved Domains (5) summary
    cd09519
    Location:362 → 425
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    PLN03192
    Location:16 → 185
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:73 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 138
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:451 → 547
    DUF4570; Domain of unknown function (DUF4570)

  8. XM_030249287.1 → XP_030105147.1  ankyrin repeat and SAM domain-containing protein 3 isoform X6

    Conserved Domains (5) summary
    cd09519
    Location:362 → 425
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    PLN03192
    Location:16 → 185
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:73 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 138
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:451 → 547
    DUF4570; Domain of unknown function (DUF4570)

  9. XM_006522611.5 → XP_006522674.1  ankyrin repeat and SAM domain-containing protein 3 isoform X4

    Conserved Domains (5) summary
    cd09519
    Location:362 → 425
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    PLN03192
    Location:16 → 185
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:73 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 138
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:451 → 547
    DUF4570; Domain of unknown function (DUF4570)

  10. XM_030249289.2 → XP_030105149.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

    Conserved Domains (3) summary
    cd09519
    Location:350 → 413
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:28 → 59
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:33 → 126
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_006522612.3 → XP_006522675.1  ankyrin repeat and SAM domain-containing protein 3 isoform X5

    Conserved Domains (4) summary
    cd09519
    Location:350 → 413
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:28 → 59
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:33 → 126
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:439 → 535
    DUF4570; Domain of unknown function (DUF4570)

  12. XM_036160145.1 → XP_036016038.1  ankyrin repeat and SAM domain-containing protein 3 isoform X12

    Conserved Domains (3) summary
    cd09519
    Location:294 → 357
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:5 → 36
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1 → 70
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_006522613.4 → XP_006522676.1  ankyrin repeat and SAM domain-containing protein 3 isoform X10

    Conserved Domains (4) summary
    cd09519
    Location:294 → 357
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    sd00045
    Location:5 → 36
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1 → 70
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:383 → 479
    DUF4570; Domain of unknown function (DUF4570)

  14. XM_030249291.2 → XP_030105151.1  ankyrin repeat and SAM domain-containing protein 3 isoform X11

    Conserved Domains (3) summary
    cd09519
    Location:250 → 313
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    pfam12796
    Location:1 → 48
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:339 → 435
    DUF4570; Domain of unknown function (DUF4570)

  15. XM_030249294.2 → XP_030105154.1  ankyrin repeat and SAM domain-containing protein 3 isoform X13

    Conserved Domains (3) summary
    cd09519
    Location:250 → 313
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    pfam12796
    Location:1 → 48
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:339 → 435
    DUF4570; Domain of unknown function (DUF4570)

  16. XM_030249292.2 → XP_030105152.1  ankyrin repeat and SAM domain-containing protein 3 isoform X11

    Conserved Domains (3) summary
    cd09519
    Location:250 → 313
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    pfam12796
    Location:1 → 48
    Ank_2; Ankyrin repeats (3 copies)
    pfam15134
    Location:339 → 435
    DUF4570; Domain of unknown function (DUF4570)

RNA

  1. XR_004939242.1 RNA Sequence

  2. XR_004939236.1 RNA Sequence

  3. XR_004939235.1 RNA Sequence

  4. XR_004939234.1 RNA Sequence

  5. XR_004939239.1 RNA Sequence

  6. XR_004939238.1 RNA Sequence

  7. XR_003951838.1 RNA Sequence

  8. XR_004939237.1 RNA Sequence

  9. XR_004939241.1 RNA Sequence

  10. XR_004939240.1 RNA Sequence

  11. XR_003951841.1 RNA Sequence

  12. XR_003951840.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZK6.2 GenPept UniProtKB/Swiss-Prot:Q9CZK6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools