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Zfp444 zinc finger protein 444 [ Mus musculus (house mouse) ]

Gene ID: 72667, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp444provided by MGI
Official Full Name
zinc finger protein 444provided by MGI
Primary source
MGI:MGI:1923365
See related
Ensembl:ENSMUSG00000044876 AllianceGenome:MGI:1923365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00134; 2810031J10Rik; 6230401O10Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain; frontal cortex; liver; placenta; and testis. Orthologous to human ZNF444 (zinc finger protein 444). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 12.1), whole brain E14.5 (RPKM 10.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp444 in Genome Data Viewer
Location:
7 A1; 7 3.58 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6175429..6196103)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6172468..6193104)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18758 Neighboring gene zinc finger protein 787 Neighboring gene STARR-positive B cell enhancer ABC_E9284 Neighboring gene predicted gene, 36371 Neighboring gene STARR-positive B cell enhancer ABC_E4893 Neighboring gene STARR-seq mESC enhancer starr_17966 Neighboring gene galanin-like peptide Neighboring gene zinc finger and SCAN domain containing 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression. Strogantsev R, et al. Genome Biol, 2015 May 30. PMID 26025256, Free PMC Article
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • FLJ00134

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 444

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146024.1 → NP_001139496.1  zinc finger protein 444

    See identical proteins and their annotated locations for NP_001139496.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC148989, AK018079, BC139361
    Consensus CDS
    CCDS20770.1
    UniProtKB/TrEMBL
    Q3TDV8, Q8BJ97
    Related
    ENSMUSP00000104206.2, ENSMUST00000108566.8
    Conserved Domains (4) summary
    COG5048
    Location:186 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain

  2. NM_028316.3 → NP_082592.2  zinc finger protein 444

    See identical proteins and their annotated locations for NP_082592.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC148989, AK018079, BC139361
    Consensus CDS
    CCDS20770.1
    UniProtKB/TrEMBL
    Q3TDV8, Q8BJ97
    Related
    ENSMUSP00000050797.6, ENSMUST00000054680.12
    Conserved Domains (4) summary
    COG5048
    Location:186 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6175429..6196103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540381.5 → XP_006540444.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_006540444.1

    UniProtKB/TrEMBL
    Q3TDV8, Q8BJ97
    Conserved Domains (4) summary
    COG5048
    Location:186 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain

  2. XM_006540382.4 → XP_006540445.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_006540445.1

    UniProtKB/TrEMBL
    Q3TDV8, Q8BJ97
    Conserved Domains (4) summary
    COG5048
    Location:186 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain

  3. XM_006540380.5 → XP_006540443.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_006540443.1

    UniProtKB/TrEMBL
    Q3TDV8, Q8BJ97
    Conserved Domains (4) summary
    COG5048
    Location:186 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain

  4. XM_006540383.5 → XP_006540446.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_006540446.1

    UniProtKB/TrEMBL
    Q3TDV8, Q8BJ97
    Conserved Domains (4) summary
    COG5048
    Location:186 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain
Nucleotide Protein Strain
Heading Accession and Version

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