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Tbcc tubulin-specific chaperone C [ Mus musculus (house mouse) ]

Gene ID: 72726, updated on 28-Oct-2024

Summary

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Official Symbol
Tbccprovided by MGI
Official Full Name
tubulin-specific chaperone Cprovided by MGI
Primary source
MGI:MGI:1919976
See related
Ensembl:ENSMUSG00000036430 AllianceGenome:MGI:1919976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810055C19Rik
Summary
Predicted to enable GTPase activity. Predicted to be involved in post-chaperonin tubulin folding pathway and tubulin complex assembly. Predicted to be located in cytosol and photoreceptor connecting cilium. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; autopod; and skeleton. Orthologous to human TBCC (tubulin folding cofactor C). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human all
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Genomic context

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See Tbcc in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47201547..47203389)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46890621..46892463)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7539 Neighboring gene STARR-positive B cell enhancer ABC_E7540 Neighboring gene STARR-seq mESC enhancer starr_42679 Neighboring gene ribosomal protein L7-like 1 Neighboring gene STARR-seq mESC enhancer starr_42682 Neighboring gene BRD4 interacting chromatin remodeling complex associated protein like Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:46965989-46966172 Neighboring gene STARR-seq mESC enhancer starr_42687 Neighboring gene STARR-seq mESC enhancer starr_42689 Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene peripherin 2 Neighboring gene ubiquitin protein ligase E3 component n-recognin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3205

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Wen HL, et al. Hum Mol Genet, 2010 May 1. PMID 20176735
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC103238

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in post-chaperonin tubulin folding pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in post-chaperonin tubulin folding pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor connecting cilium ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor connecting cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tubulin-specific chaperone C
Names
CFC
tubulin-folding cofactor C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178385.3 → NP_848472.2  tubulin-specific chaperone C

    See identical proteins and their annotated locations for NP_848472.2

    Status: VALIDATED

    Source sequence(s)
    AK132036, BY299869
    Consensus CDS
    CCDS28843.1
    UniProtKB/Swiss-Prot
    Q3V242, Q8VCN9
    UniProtKB/TrEMBL
    A0A0R4J0M1
    Related
    ENSMUSP00000048696.8, ENSMUST00000040434.9
    Conserved Domains (2) summary
    pfam07986
    Location:199 → 316
    TBCC; Tubulin binding cofactor C
    pfam16752
    Location:28 → 134
    TBCC_N; Tubulin-specific chaperone C N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47201547..47203389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCN9.1 GenPept UniProtKB/Swiss-Prot:Q8VCN9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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