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Pdxp pyridoxal phosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 727679, updated on 14-Nov-2024

Summary

Official Symbol
Pdxpprovided by RGD
Official Full Name
pyridoxal phosphataseprovided by RGD
Primary source
RGD:1586212
See related
EnsemblRapid:ENSRNOG00000009570 AllianceGenome:RGD:1586212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rbp1
Summary
Enables growth factor binding activity. Predicted to be involved in several processes, including positive regulation of actin filament depolymerization; pyridoxal phosphate catabolic process; and regulation of cell cycle process. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Predicted to be located in several cellular components, including cleavage furrow; midbody; and ruffle membrane. Predicted to be active in cytosol; glutamatergic synapse; and postsynapse. Orthologous to human PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 214.0), Adrenal (RPKM 47.5) and 7 other tissues See more
Orthologs
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Genomic context

See Pdxp in Genome Data Viewer
Location:
7q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112352971..112358419)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110472515..110477963)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120140460..120145908)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093687 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene SH3-domain binding protein 1 Neighboring gene uncharacterized LOC134479755 Neighboring gene galectin 1 Neighboring gene nucleolar protein 12

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyridoxal phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in actin rod assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within actin rod assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ATP IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pyridoxal phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyridoxal phosphate catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pyridoxal phosphate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of modification of postsynaptic structure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of modification of postsynaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in contractile ring IEA
Inferred from Electronic Annotation
more info
 
located_in contractile ring ISO
Inferred from Sequence Orthology
more info
 
located_in contractile ring ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
chronophin
Names
PLP phosphatase
pyridoxal (pyridoxine, vitamin B6) phosphatase
pyridoxal phosphate phosphatase
reg I binding protein I
reg I-binding protein 1
NP_001129291.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135819.1NP_001129291.1  chronophin

    See identical proteins and their annotated locations for NP_001129291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166563
    UniProtKB/Swiss-Prot
    Q8VD52
    UniProtKB/TrEMBL
    B2GV79
    Related
    ENSRNOP00000050300.3, ENSRNOT00000040513.5
    Conserved Domains (1) summary
    TIGR01452
    Location:18286
    PGP_euk; phosphoglycolate/pyridoxal phosphate phosphatase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112352971..112358419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)