NXF2B nuclear RNA export factor 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: NXF2Bprovided by HGNC
Official Full Name: nuclear RNA export factor 2Bprovided by HGNC
Primary source: HGNC:HGNC:23984
See related: Ensembl:ENSG00000269437 AllianceGenome:HGNC:23984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCP11X2; bA353J17.1
Summary: This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 2015]
Expression: Restricted expression toward testis (RPKM 9.5) See more
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Genomic context

Location:: Xq22.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (102360395..102440008, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (100804941..100884503, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (101615316..101694929, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF020177 (e-PCR)
- UniSTS:43538

sWXD3381 (e-PCR)
- UniSTS:99367

NoName (e-PCR)
- UniSTS:482102

RH103532 (e-PCR)
- UniSTS:97857

G65767 (e-PCR)
- UniSTS:225902

Clone Names

FLJ20416, FLJ32823, FLJ54838, FLJ98203, DKFZp434B1612, DKFZp686N2036

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA export from nucleus	NAS Non-traceable Author Statement more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
part_of nuclear RNA export factor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of nuclear RNA export factor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear RNA export factor complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear RNA export factor 2

Names: T-complex protein 11 X-linked protein 2; TAP-like protein 2; cancer/testis antigen 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099686.3 → NP_001093156.1 nuclear RNA export factor 2

See identical proteins and their annotated locations for NP_001093156.1

Status: VALIDATED

Source sequence(s)

AC235565, AK000423, AK308255

Consensus CDS

CCDS43979.1

UniProtKB/Swiss-Prot

Q9BXU4, Q9GZY0, Q9NSS1, Q9NX66

Related

ENSP00000472530.1, ENST00000602195.6

Conserved Domains (5) summary

smart00804
Location:570 → 623

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:229 → 271

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:121 → 203

Tap-RNA_bind; Tap, RNA-binding

pfam13855
Location:270 → 332

LRR_8; Leucine rich repeat

cl09109
Location:391 → 543

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...