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USP17L29 ubiquitin specific peptidase 17 like family member 29 [ Homo sapiens (human) ]

Gene ID: 728405, updated on 2-Nov-2024

Summary

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Official Symbol
USP17L29provided by HGNC
Official Full Name
ubiquitin specific peptidase 17 like family member 29provided by HGNC
Primary source
HGNC:HGNC:44457
See related
Ensembl:ENSG00000231637 AllianceGenome:HGNC:44457
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See USP17L29 in Genome Data Viewer
Location:
4p16.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (9353638..9355230)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (9374159..9375751)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9355364..9356956)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 17 like family member 27 Neighboring gene ubiquitin specific peptidase 17 like family member 28 Neighboring gene ubiquitin specific peptidase 17 like family member 9, pseudogene Neighboring gene ubiquitin specific peptidase 17 like family member 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cdc25A and Dub3 in a high-stakes balancing act. Hayes SD, et al. Nat Cell Biol, 2010 Apr. PMID 20228807
  2. Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. Gondo Y, et al. Genomics, 1998 Nov 15. PMID 9806828
  3. The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. Saitoh Y, et al. Genomics, 2000 Aug 1. PMID 10936051
  4. Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. Okada T, et al. Hum Genet, 2002 Apr. PMID 11941478
  5. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. Shin JM, et al. BMC Genomics, 2006 Nov 16. PMID 17109758, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
ubiquitin specific peptidase 17 like family member 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242332.1 → NP_001229261.1  ubiquitin specific peptidase 17 like family member 29

    See identical proteins and their annotated locations for NP_001229261.1

    Status: INFERRED

    Source sequence(s)
    AC116655
    Consensus CDS
    CCDS59470.1
    UniProtKB/Swiss-Prot
    A8MRA9, Q0WX56, Q0WX57, Q3BEM1
    UniProtKB/TrEMBL
    A0AAG2TI18
    Related
    ENSP00000422969.1, ENST00000511681.1
    Conserved Domains (2) summary
    cd02661
    Location:79 → 373
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam04774
    Location:430 → 454
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    9353638..9355230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    9374159..9375751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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