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Lrrc47 leucine rich repeat containing 47 [ Mus musculus (house mouse) ]

Gene ID: 72946, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc47provided by MGI
Official Full Name
leucine rich repeat containing 47provided by MGI
Primary source
MGI:MGI:1920196
See related
Ensembl:ENSMUSG00000029028 AllianceGenome:MGI:1920196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1185; 2900010D03Rik
Summary
Predicted to enable RNA binding activity. Predicted to contribute to phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Is expressed in central nervous system and retina. Orthologous to human LRRC47 (leucine rich repeat containing 47). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 63.9), thymus adult (RPKM 42.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc47 in Genome Data Viewer
Location:
4 E2; 4 83.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154096260..154105969)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154011803..154021512)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor, beta subunit Neighboring gene centrosomal protein 104 Neighboring gene predicted gene, 31566 Neighboring gene small integral membrane protein 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene transformation related protein 73 Neighboring gene STARR-seq mESC enhancer starr_12227 Neighboring gene STARR-seq mESC enhancer starr_12228 Neighboring gene predicted gene, 26036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
  2. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
  3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
contributes_to phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201226.1 → NP_957678.1  leucine-rich repeat-containing protein 47

    See identical proteins and their annotated locations for NP_957678.1

    Status: VALIDATED

    Source sequence(s)
    AK013512, AK129306, BU148242, BU514662
    Consensus CDS
    CCDS19006.1
    UniProtKB/Swiss-Prot
    Q3U380, Q505F5, Q6ZPW2, Q9CUZ0
    UniProtKB/TrEMBL
    B1AX98, E9PV22
    Related
    ENSMUSP00000030894.9, ENSMUST00000030894.15
    Conserved Domains (4) summary
    smart00873
    Location:332 → 504
    B3_4; B3/4 domain
    cd00116
    Location:34 → 260
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:54 → 78
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 143
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154096260..154105969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505F5.1 GenPept UniProtKB/Swiss-Prot:Q505F5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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