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Hspa12a heat shock protein 12A [ Mus musculus (house mouse) ]

Gene ID: 73442, updated on 2-Nov-2024

Summary

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Official Symbol
Hspa12aprovided by MGI
Official Full Name
heat shock protein 12Aprovided by MGI
Primary source
MGI:MGI:1920692
See related
Ensembl:ENSMUSG00000025092 AllianceGenome:MGI:1920692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Mgi40; Gm19925; mKIAA0417; 1700063D12Rik
Summary
Predicted to enable ATP binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in nervous system; retina; and white fat. Orthologous to human HSPA12A (heat shock protein family A (Hsp70) member 12A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 20.3), CNS E18 (RPKM 18.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Hspa12a in Genome Data Viewer
Location:
19 D2; 19 54.51 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58784182..58932104, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58795750..58943672, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52394 Neighboring gene sperm microtubule inner protein 5 Neighboring gene predicted gene, 41877 Neighboring gene STARR-positive B cell enhancer ABC_E10000 Neighboring gene STARR-seq mESC enhancer starr_46586 Neighboring gene predicted gene, 52393 Neighboring gene STARR-seq mESC enhancer starr_46588 Neighboring gene microRNA 3086 Neighboring gene enolase 4 Neighboring gene STARR-seq mESC enhancer starr_46589 Neighboring gene shootin 1 Neighboring gene predicted gene, 57667

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury. Yu W, et al. JCI Insight, 2024 Apr 8. PMID 38421727, Free PMC Article
  2. HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization. Wang J, et al. Transl Psychiatry, 2023 Aug 14. PMID 37580315, Free PMC Article
  3. Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes. Du S, et al. Theranostics, 2023. PMID 37441587, Free PMC Article
  4. Roles of heat shock protein A12A in the development of diabetic cardiomyopathy. Jia Y, et al. Cell Stress Chaperones, 2024 Apr. PMID 38485044, Free PMC Article
  5. HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization. Kong Q, et al. Diabetes, 2019 Feb. PMID 30455376

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of heat shock protein A12A in the development of diabetic cardiomyopathy.
    Title: Roles of heat shock protein A12A in the development of diabetic cardiomyopathy.
  2. HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury.
    Title: HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury.
  3. HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.
    Title: HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.
  4. HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction.
    Title: HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction.
  5. HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1alpha-dependent acyloxyacyl hydrolase expression.
    Title: HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression.
  6. HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARgamma.
    Title: HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ.
  7. Deficiency of Hspa12a promotes browning of white adipose tissues in mice.
    Title: Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice.
  8. findings suggest that HSPA12A expression encodes a critical novel prosurvival pathway during ischaemic stroke.
    Title: Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke.
  9. HSPA12A and HSPA12B may play roles in genetic susceptibility to atherosclerosis
    Title: Two Hsp70 family members expressed in atherosclerotic lesions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock 70 kDa protein 12A
Names
heat shock 70kDa protein 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327998.1 → NP_001314927.1  heat shock 70 kDa protein 12A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK087732, AK141925, BQ176746, BY240671
    UniProtKB/Swiss-Prot
    Q8K0U4
    Conserved Domains (1) summary
    cd11735
    Location:75 → 541
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

  2. NM_175199.3 → NP_780408.1  heat shock 70 kDa protein 12A isoform 2

    See identical proteins and their annotated locations for NP_780408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK141925
    Consensus CDS
    CCDS38032.1
    UniProtKB/Swiss-Prot
    Q3UQZ8, Q8CHF6, Q8K0U4
    Related
    ENSMUSP00000066860.5, ENSMUST00000066285.6
    Conserved Domains (1) summary
    cd11735
    Location:57 → 523
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    58784182..58932104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247368.4 → XP_011245670.1  heat shock 70 kDa protein 12A isoform X2

    Conserved Domains (1) summary
    cd11735
    Location:46 → 512
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

  2. XM_006527377.3 → XP_006527440.1  heat shock 70 kDa protein 12A isoform X1

    Conserved Domains (1) summary
    cd11735
    Location:77 → 543
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

  3. XM_006527379.5 → XP_006527442.1  heat shock 70 kDa protein 12A isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:1 → 440
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_036161702.1 → XP_036017595.1  heat shock 70 kDa protein 12A isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:24 → 268
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_036161704.1 → XP_036017597.1  heat shock 70 kDa protein 12A isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:24 → 268
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  6. XM_036161703.1 → XP_036017596.1  heat shock 70 kDa protein 12A isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:24 → 268
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0U4.1 GenPept UniProtKB/Swiss-Prot:Q8K0U4

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