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Tssk5 testis-specific serine kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 73542, updated on 2-Nov-2024

Summary

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Official Symbol
Tssk5provided by MGI
Official Full Name
testis-specific serine kinase 5provided by MGI
Primary source
MGI:MGI:1920792
See related
Ensembl:ENSMUSG00000060794 AllianceGenome:MGI:1920792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TSK-5; 1700091F14Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in metanephros; submandibular gland; and testis. Orthologous to human TSSK5P (testis specific serine kinase 5, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 21.6) See more
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Genomic context

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See Tssk5 in Genome Data Viewer
Location:
15 D3; 15 35.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76256158..76259391, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76371958..76375191, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39052 Neighboring gene WD repeat domain 97 Neighboring gene STARR-positive B cell enhancer ABC_E11592 Neighboring gene STARR-positive B cell enhancer ABC_E1912 Neighboring gene HGH1 homolog Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene block of proliferation 1 Neighboring gene scleraxis scleraxis bHLH transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-specific serine/threonine-protein kinase 5
Names
testis-specific kinase 5
NP_898922.2
XP_011244046.1
XP_011244047.1
XP_011244048.1
XP_011244049.1
XP_011244050.1
XP_017172248.1
XP_030104654.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183099.2 → NP_898922.2  testis-specific serine/threonine-protein kinase 5

    See identical proteins and their annotated locations for NP_898922.2

    Status: VALIDATED

    Source sequence(s)
    AK007032, BC114543
    Consensus CDS
    CCDS37122.1
    UniProtKB/Swiss-Prot
    Q1WWK7, Q8C1R0
    Related
    ENSMUSP00000071120.7, ENSMUST00000071119.8
    Conserved Domains (2) summary
    smart00220
    Location:31 → 302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:26 → 301
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76256158..76259391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248794.1 → XP_030104654.1  testis-specific serine/threonine-protein kinase 5 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:2 → 236
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017316759.2 → XP_017172248.1  testis-specific serine/threonine-protein kinase 5 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:26 → 254
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011245744.3 → XP_011244046.1  testis-specific serine/threonine-protein kinase 5 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:26 → 301
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011245745.3 → XP_011244047.1  testis-specific serine/threonine-protein kinase 5 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:26 → 295
    PKc_like; Protein Kinases, catalytic domain

  5. XM_011245748.3 → XP_011244050.1  testis-specific serine/threonine-protein kinase 5 isoform X5

    See identical proteins and their annotated locations for XP_011244050.1

    Conserved Domains (1) summary
    cl21453
    Location:26 → 235
    PKc_like; Protein Kinases, catalytic domain

  6. XM_011245746.3 → XP_011244048.1  testis-specific serine/threonine-protein kinase 5 isoform X5

    See identical proteins and their annotated locations for XP_011244048.1

    Conserved Domains (1) summary
    cl21453
    Location:26 → 235
    PKc_like; Protein Kinases, catalytic domain

  7. XM_011245747.3 → XP_011244049.1  testis-specific serine/threonine-protein kinase 5 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:26 → 237
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_875314.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1R0.2 GenPept UniProtKB/Swiss-Prot:Q8C1R0

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