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Cfap141 cilia and flagella associated protein 141 [ Mus musculus (house mouse) ]

Gene ID: 73545, updated on 2-Nov-2024

Summary

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Official Symbol
Cfap141provided by MGI
Official Full Name
cilia and flagella associated protein 141provided by MGI
Primary source
MGI:MGI:1920795
See related
Ensembl:ENSMUSG00000118506 AllianceGenome:MGI:1920795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700094D03Rik
Summary
Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human CFAP141 (cilia and flagella associated protein 141). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 6.6), lung adult (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cfap141 in Genome Data Viewer
Location:
3 F1; 3 39.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89970115..89975654)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90062808..90068347)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 2-like Neighboring gene microRNA 7669 Neighboring gene RIKEN cDNA 4933434E20 gene Neighboring gene STARR-seq mESC enhancer starr_08270 Neighboring gene STARR-seq mESC enhancer starr_08271 Neighboring gene microRNA 190b Neighboring gene STARR-positive B cell enhancer ABC_E3447 Neighboring gene STARR-positive B cell enhancer ABC_E7923 Neighboring gene STARR-seq mESC enhancer starr_08272 Neighboring gene tropomyosin 3, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
  2. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
  3. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cilia- and flagella-associated protein 141
Names
protein CFAP141
uncharacterized protein C1orf189 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028567.2 → NP_082843.2  cilia- and flagella-associated protein 141

    Status: VALIDATED

    Source sequence(s)
    AC163616
    Consensus CDS
    CCDS50968.2
    UniProtKB/Swiss-Prot
    Q9D9D9
    Related
    ENSMUSP00000158884.2, ENSMUST00000238911.2
    Conserved Domains (1) summary
    pfam15104
    Location:15 → 100
    DUF4558; Domain of unknown function (DUF4558)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89970115..89975654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9D9.2 GenPept UniProtKB/Swiss-Prot:Q9D9D9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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