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Mvb12a multivesicular body subunit 12A [ Mus musculus (house mouse) ]

Gene ID: 73711, updated on 28-Oct-2024

Summary

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Official Symbol
Mvb12aprovided by MGI
Official Full Name
multivesicular body subunit 12Aprovided by MGI
Primary source
MGI:MGI:1920961
See related
Ensembl:ENSMUSG00000031813 AllianceGenome:MGI:1920961
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam125a; 1110012M11Rik
Summary
Predicted to enable lipid binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in centrosome; intracellular membrane-bounded organelle; and vesicle. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 37.7), adrenal adult (RPKM 34.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mvb12a in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71995552..72000670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71542907..71548026)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like Neighboring gene STARR-seq mESC enhancer starr_21821 Neighboring gene STARR-positive B cell enhancer ABC_E1759 Neighboring gene bone marrow stromal cell antigen 2 Neighboring gene STARR-positive B cell enhancer ABC_E6652 Neighboring gene transmembrane protein 221 Neighboring gene STARR-positive B cell enhancer ABC_E6653 Neighboring gene nucleoredoxin-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99951

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in viral budding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral budding IEA
Inferred from Electronic Annotation
more info
  
involved_in viral budding ISO
Inferred from Sequence Orthology
more info
  
involved_in virus maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in virus maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in virus maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
multivesicular body subunit 12A
Names
ESCRT-I complex subunit MVB12A
family with sequence similarity 125, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028617.2 → NP_082893.1  multivesicular body subunit 12A

    See identical proteins and their annotated locations for NP_082893.1

    Status: PROVISIONAL

    Source sequence(s)
    BC020119
    Consensus CDS
    CCDS22398.1
    UniProtKB/Swiss-Prot
    Q78HU3
    Related
    ENSMUSP00000034272.8, ENSMUST00000034272.9
    Conserved Domains (1) summary
    pfam10240
    Location:9 → 259
    DUF2464; Protein of unknown function (DUF2464)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71995552..72000670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243804.2 → XP_030099664.1  multivesicular body subunit 12A isoform X1

    Conserved Domains (1) summary
    pfam10240
    Location:1 → 157
    DUF2464; Multivesicular body subunit 12

  2. XM_011242330.4 → XP_011240632.2  multivesicular body subunit 12A isoform X1

    Conserved Domains (1) summary
    pfam10240
    Location:1 → 157
    DUF2464; Multivesicular body subunit 12
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78HU3.1 GenPept UniProtKB/Swiss-Prot:Q78HU3

Gene LinkOut

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