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Herc3 hect domain and RLD 3 [ Mus musculus (house mouse) ]

Gene ID: 73998, updated on 2-Nov-2024

Summary

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Official Symbol
Herc3provided by MGI
Official Full Name
hect domain and RLD 3provided by MGI
Primary source
MGI:MGI:1921248
See related
Ensembl:ENSMUSG00000029804 AllianceGenome:MGI:1921248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0032; 5730409F18Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in embryo mesenchyme; esophagus; lung; nervous system; and sensory organ. Orthologous to human HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 14.6), frontal lobe adult (RPKM 10.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Herc3 in Genome Data Viewer
Location:
6 B3; 6 27.82 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (58808440..58897383)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (58831455..58920398)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) Neighboring gene STARR-seq mESC enhancer starr_16022 Neighboring gene STARR-seq mESC enhancer starr_16023 Neighboring gene predicted gene, 38822 Neighboring gene STARR-seq mESC enhancer starr_16024 Neighboring gene STARR-seq mESC enhancer starr_16025 Neighboring gene STARR-seq mESC enhancer starr_16026 Neighboring gene STARR-seq mESC enhancer starr_16027 Neighboring gene STARR-seq mESC enhancer starr_16029 Neighboring gene nucleosome assembly protein 1-like 5 Neighboring gene RIKEN cDNA 8430415O14 gene Neighboring gene family with sequence similarity 13, member A Neighboring gene TPX2, microtubule-associated protein homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration. Zegeye Y, et al. Sci Rep, 2024 Feb 6. PMID 38321224, Free PMC Article
  2. Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus. Cowley M, et al. Nucleic Acids Res, 2012 Oct. PMID 22790983, Free PMC Article
  3. Optimising experimental design for high-throughput phenotyping in mice: a case study. Karp NA, et al. Mamm Genome, 2010 Oct. PMID 20799038, Free PMC Article
  4. Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration. Li X, et al. Life Sci, 2023 May 1. PMID 36878279
  5. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.
    Title: E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.
  2. Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.
    Title: Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.
  3. Allele-specific polyadenylation occurs at the imprinted Herc3/Nap1l5 locus.
    Title: Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30404

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC3
NP_001348895.1
NP_001348896.1
NP_082981.3
XP_006506759.1
XP_006506760.1
XP_006506761.1
XP_006506764.1
XP_011239792.1
XP_030111494.1
XP_030111495.1
XP_036008252.1
XP_036008253.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361966.1 → NP_001348895.1  probable E3 ubiquitin-protein ligase HERC3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC115881, AC166819
    Consensus CDS
    CCDS20196.1
    UniProtKB/TrEMBL
    A6H6S0, Q8CFQ0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. NM_001361967.1 → NP_001348896.1  probable E3 ubiquitin-protein ligase HERC3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC115881, AC166819, AK017531
    Consensus CDS
    CCDS90054.1
    UniProtKB/TrEMBL
    G5E876, Q9CYM1
    Related
    ENSMUSP00000031823.6, ENSMUST00000031823.12
    Conserved Domains (3) summary
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl27008
    Location:702 → 887
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 331
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. NM_028705.3 → NP_082981.3  probable E3 ubiquitin-protein ligase HERC3 isoform a

    See identical proteins and their annotated locations for NP_082981.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC042574, BC145980
    Consensus CDS
    CCDS20196.1
    UniProtKB/TrEMBL
    A6H6S0, Q8CFQ0
    Related
    ENSMUSP00000040025.9, ENSMUST00000041401.11
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    58808440..58897383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506696.3 → XP_006506759.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

    See identical proteins and their annotated locations for XP_006506759.1

    UniProtKB/TrEMBL
    A6H6S0, Q8CFQ0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_006506701.5 → XP_006506764.1  probable E3 ubiquitin-protein ligase HERC3 isoform X3

    Conserved Domains (2) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. XM_006506698.5 → XP_006506761.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

    See identical proteins and their annotated locations for XP_006506761.1

    UniProtKB/TrEMBL
    A6H6S0, Q8CFQ0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  4. XM_030255635.2 → XP_030111495.1  probable E3 ubiquitin-protein ligase HERC3 isoform X2

    Conserved Domains (1) summary
    cd00078
    Location:320 → 666
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  5. XM_030255634.2 → XP_030111494.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

    UniProtKB/TrEMBL
    A6H6S0, Q8CFQ0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  6. XM_006506697.5 → XP_006506760.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

    See identical proteins and their annotated locations for XP_006506760.1

    UniProtKB/TrEMBL
    A6H6S0, Q8CFQ0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:702 → 1048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313 → 377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  7. XM_036152359.1 → XP_036008252.1  probable E3 ubiquitin-protein ligase HERC3 isoform X2

    Conserved Domains (1) summary
    cd00078
    Location:320 → 666
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  8. XM_036152360.1 → XP_036008253.1  probable E3 ubiquitin-protein ligase HERC3 isoform X4

    Conserved Domains (1) summary
    cd00078
    Location:280 → 626
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  9. XM_011241490.3 → XP_011239792.1  probable E3 ubiquitin-protein ligase HERC3 isoform X5

    Conserved Domains (1) summary
    cd00078
    Location:191 → 537
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. XR_003956257.1 RNA Sequence

  2. XR_377496.4 RNA Sequence

  3. XR_377495.4 RNA Sequence

  4. XR_001785176.3 RNA Sequence

  5. XR_001785177.3 RNA Sequence

  6. XR_001785178.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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