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Rin2 Ras and Rab interactor 2 [ Mus musculus (house mouse) ]

Gene ID: 74030, updated on 28-Oct-2024

Summary

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Official Symbol
Rin2provided by MGI
Official Full Name
Ras and Rab interactor 2provided by MGI
Primary source
MGI:MGI:1921280
See related
Ensembl:ENSMUSG00000001768 AllianceGenome:MGI:1921280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RASSF4; 2010003K16Rik; 4632403N06Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of vasculogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 13.6), limb E14.5 (RPKM 10.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rin2 in Genome Data Viewer
Location:
2 G1; 2 71.25 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145613647..145729536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145771727..145887616)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC039771 Neighboring gene predicted gene, 54120 Neighboring gene predicted gene, 34513 Neighboring gene STARR-seq mESC enhancer starr_05929 Neighboring gene predicted gene, 54121 Neighboring gene STARR-seq mESC enhancer starr_05932 Neighboring gene predicted gene, 39954 Neighboring gene STARR-seq mESC enhancer starr_05933 Neighboring gene STARR-positive B cell enhancer ABC_E8796 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. Qiao L, et al. Cell Signal, 2023 Dec. PMID 37827343
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
    Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras and Rab interactor 2
Names
ras interaction/interference protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001406508.1 → NP_001393437.1  ras and Rab interactor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672100
    UniProtKB/Swiss-Prot
    A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684

  2. NM_001406509.1 → NP_001393438.1  ras and Rab interactor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672100
    UniProtKB/Swiss-Prot
    A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
    Related
    ENSMUSP00000105632.2, ENSMUST00000110005.8

  3. NM_001406510.1 → NP_001393439.1  ras and Rab interactor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672100

  4. NM_028724.5 → NP_083000.5  ras and Rab interactor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672100
    Consensus CDS
    CCDS50734.1
    UniProtKB/TrEMBL
    F8WGD2
    Related
    ENSMUSP00000092053.5, ENSMUST00000094480.11
    Conserved Domains (3) summary
    smart00167
    Location:614 → 730
    VPS9; Domain present in VPS9
    cd10394
    Location:41 → 140
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:751 → 841
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145613647..145729536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500269.1 → XP_006500332.1  ras and Rab interactor 2 isoform X1

    See identical proteins and their annotated locations for XP_006500332.1

    UniProtKB/Swiss-Prot
    A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
    Conserved Domains (3) summary
    smart00167
    Location:659 → 775
    VPS9; Domain present in VPS9
    cd10394
    Location:86 → 185
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:796 → 886
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

  2. XM_036162625.1 → XP_036018518.1  ras and Rab interactor 2 isoform X2

    Conserved Domains (3) summary
    smart00167
    Location:606 → 722
    VPS9; Domain present in VPS9
    cd10394
    Location:33 → 132
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:743 → 833
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D684.3 GenPept UniProtKB/Swiss-Prot:Q9D684

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