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Krt80 keratin 80 [ Mus musculus (house mouse) ]

Gene ID: 74127, updated on 2-Nov-2024

Summary

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Official Symbol
Krt80provided by MGI
Official Full Name
keratin 80provided by MGI
Primary source
MGI:MGI:1921377
See related
Ensembl:ENSMUSG00000037185 AllianceGenome:MGI:1921377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K80; Kb20; CK-80; 1200016G03Rik; 2310041I20Rik
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in keratin filament. Is expressed in molar; naris; renal calyx; submandibular gland primordium; and vibrissa. Orthologous to human KRT80 (keratin 80). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 47.4), stomach adult (RPKM 18.2) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Krt80 in Genome Data Viewer
Location:
15 F1; 15 56.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101246196..101268043, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101348315..101370162, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 41 Neighboring gene predicted gene, 41403 Neighboring gene predicted gene, 52200 Neighboring gene predicted gene, 35853 Neighboring gene microRNA 1941 Neighboring gene predicted gene 671 Neighboring gene STARR-seq mESC enhancer starr_39796 Neighboring gene keratin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice. Smithson G, et al. J Exp Med, 1994 Aug 1. PMID 8046347, Free PMC Article
  2. Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly. Bray DJ, et al. PLoS One, 2015. PMID 26181054, Free PMC Article
  3. Tracing the origin of hair follicle stem cells. Morita R, et al. Nature, 2021 Jun. PMID 34108685
  4. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
keratin, type II cytoskeletal 80
Names
cytokeratin-80
type-II keratin Kb20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028770.3 → NP_083046.2  keratin, type II cytoskeletal 80

    See identical proteins and their annotated locations for NP_083046.2

    Status: VALIDATED

    Source sequence(s)
    AC163018, AK004811, BB843716, BC120601
    Consensus CDS
    CCDS37216.1
    UniProtKB/Swiss-Prot
    Q0VBK2
    Related
    ENSMUSP00000076437.5, ENSMUST00000077196.6
    Conserved Domains (2) summary
    pfam00038
    Location:82 → 393
    Filament; Intermediate filament protein
    pfam16208
    Location:9 → 78
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101246196..101268043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521487.4 → XP_006521550.1  keratin, type II cytoskeletal 80 isoform X1

    UniProtKB/TrEMBL
    Q3TBQ1
    Conserved Domains (1) summary
    pfam00038
    Location:1 → 178
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VBK2.1 GenPept UniProtKB/Swiss-Prot:Q0VBK2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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