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Ctbs chitobiase [ Mus musculus (house mouse) ]

Gene ID: 74245, updated on 2-Nov-2024

Summary

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Official Symbol
Ctbsprovided by MGI
Official Full Name
chitobiaseprovided by MGI
Primary source
MGI:MGI:1921495
See related
Ensembl:ENSMUSG00000028189 AllianceGenome:MGI:1921495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTB; 2210401K11Rik
Summary
Predicted to enable chitinase activity. Predicted to be involved in chitin catabolic process and oligosaccharide catabolic process. Predicted to be located in lysosome. Is expressed in ventricular layer. Orthologous to human CTBS (chitobiase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.4), kidney adult (RPKM 3.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ctbs in Genome Data Viewer
Location:
3 H2; 3 71.26 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146156204..146171604)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146450449..146465849)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22078 Neighboring gene SSX family member 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9230 Neighboring gene spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene G protein subunit gamma 5 Neighboring gene STARR-positive B cell enhancer ABC_E11229 Neighboring gene ribosome production factor 1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2. Persichetti E, et al. Biochim Biophys Acta, 2012 Jul. PMID 22465033
  2. Molecular cloning and structural organization of the gene encoding the mouse lysosomal di-N-acetylchitobiase (ctbs). Balducci C, et al. Gene, 2008 Jun 15. PMID 18440730
  3. New paralogues and revised time line in the expansion of the vertebrate GH18 family. Hussain M, et al. J Mol Evol, 2013 Apr. PMID 23558346
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals.
    Title: Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
di-N-acetylchitobiase
Names
chitobiase, di-N-acetyl-
NP_001280601.1
NP_083112.1
XP_030108705.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293672.2 → NP_001280601.1  di-N-acetylchitobiase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001280601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124987
    Consensus CDS
    CCDS80048.1
    UniProtKB/Swiss-Prot
    Q8R242, Q9D7V4
    UniProtKB/TrEMBL
    Q102J0
    Related
    ENSMUSP00000059167.7, ENSMUST00000061937.13
    Conserved Domains (2) summary
    cd02875
    Location:24 → 362
    GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...
    smart00636
    Location:99 → 342
    Glyco_18; Glyco_18 domain

  2. NM_028836.5 → NP_083112.1  di-N-acetylchitobiase isoform 2 precursor

    See identical proteins and their annotated locations for NP_083112.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC124987
    Consensus CDS
    CCDS17902.1
    UniProtKB/Swiss-Prot
    Q8R242
    Related
    ENSMUSP00000029840.4, ENSMUST00000029840.4
    Conserved Domains (2) summary
    smart00636
    Location:99 → 288
    Glyco_18; Glyco_18 domain
    cl10447
    Location:24 → 308
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

RNA

  1. NR_190655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124987

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146156204..146171604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252845.1 → XP_030108705.1  di-N-acetylchitobiase isoform X1

    Conserved Domains (1) summary
    cl10447
    Location:1 → 244
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R242.2 GenPept UniProtKB/Swiss-Prot:Q8R242

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