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Ankrd9 ankyrin repeat domain 9 [ Mus musculus (house mouse) ]

Gene ID: 74251, updated on 2-Nov-2024

Summary

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Official Symbol
Ankrd9provided by MGI
Official Full Name
ankyrin repeat domain 9provided by MGI
Primary source
MGI:MGI:1921501
See related
Ensembl:ENSMUSG00000037904 AllianceGenome:MGI:1921501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2500003O20Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in intracellular copper ion homeostasis; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ANKRD9 (ankyrin repeat domain 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 50.8), small intestine adult (RPKM 40.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd9 in Genome Data Viewer
Location:
12 F1; 12 60.9 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110942854..110945516, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110976420..110979082, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1157 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene ribosomal protein S19, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_33311 Neighboring gene STARR-positive B cell enhancer ABC_E10773 Neighboring gene STARR-positive B cell enhancer ABC_E7183 Neighboring gene predicted gene, 51959 Neighboring gene RIKEN cDNA 6030440G07 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular copper ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular copper ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul5-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361916.1 → NP_001348845.1  ankyrin repeat domain-containing protein 9

    Status: VALIDATED

    Source sequence(s)
    AC153152
    Consensus CDS
    CCDS26174.1
    UniProtKB/Swiss-Prot
    Q3TA09, Q8BH83, Q8BHR3
    UniProtKB/TrEMBL
    D3Z2N1
    Related
    ENSMUSP00000119339.2, ENSMUST00000135131.2
    Conserved Domains (2) summary
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:156 → 197
    Ank_5; Ankyrin repeats (many copies)

  2. NM_001361917.1 → NP_001348846.1  ankyrin repeat domain-containing protein 9

    Status: VALIDATED

    Source sequence(s)
    AC153152
    Consensus CDS
    CCDS26174.1
    UniProtKB/Swiss-Prot
    Q3TA09, Q8BH83, Q8BHR3
    UniProtKB/TrEMBL
    D3Z2N1
    Related
    ENSMUSP00000121279.2, ENSMUST00000140788.8
    Conserved Domains (2) summary
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:156 → 197
    Ank_5; Ankyrin repeats (many copies)

  3. NM_175207.5 → NP_780416.2  ankyrin repeat domain-containing protein 9

    See identical proteins and their annotated locations for NP_780416.2

    Status: VALIDATED

    Source sequence(s)
    AK032641, AK051108
    Consensus CDS
    CCDS26174.1
    UniProtKB/Swiss-Prot
    Q3TA09, Q8BH83, Q8BHR3
    UniProtKB/TrEMBL
    D3Z2N1
    Related
    ENSMUSP00000120816.2, ENSMUST00000128353.8
    Conserved Domains (2) summary
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:156 → 197
    Ank_5; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110942854..110945516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516294.5 → XP_006516357.1  ankyrin repeat domain-containing protein 9 isoform X1

    See identical proteins and their annotated locations for XP_006516357.1

    UniProtKB/Swiss-Prot
    Q3TA09, Q8BH83, Q8BHR3
    UniProtKB/TrEMBL
    D3Z2N1
    Conserved Domains (2) summary
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:156 → 197
    Ank_5; Ankyrin repeats (many copies)

  2. XM_030246958.2 → XP_030102818.1  ankyrin repeat domain-containing protein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q3TA09, Q8BH83, Q8BHR3
    UniProtKB/TrEMBL
    D3Z2N1
    Conserved Domains (2) summary
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:156 → 197
    Ank_5; Ankyrin repeats (many copies)

  3. XM_030246957.2 → XP_030102817.1  ankyrin repeat domain-containing protein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q3TA09, Q8BH83, Q8BHR3
    UniProtKB/TrEMBL
    D3Z2N1
    Conserved Domains (2) summary
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:156 → 197
    Ank_5; Ankyrin repeats (many copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH83.1 GenPept UniProtKB/Swiss-Prot:Q8BH83

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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