U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 [ Mus musculus (house mouse) ]

Gene ID: 74338, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Slc6a19provided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter), member 19provided by MGI
Primary source
MGI:MGI:1921588
See related
Ensembl:ENSMUSG00000021565 AllianceGenome:MGI:1921588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B<0>AT1; 4632401C08Rik
Summary
Enables neutral L-amino acid transmembrane transporter activity. Acts upstream of or within neutral amino acid transport. Located in apical plasma membrane and brush border membrane. Is expressed in blastocyst; cumulus oophorus; early embryo; and metanephros. Used to study Hartnup disease. Human ortholog(s) of this gene implicated in Hartnup disease. Orthologous to human SLC6A19 (solute carrier family 6 member 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 169.0), large intestine adult (RPKM 126.9) and 2 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc6a19 in Genome Data Viewer
Location:
13 C1; 13 40.14 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73827864..73848899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73679745..73700780, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Tert 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_34994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:73778847-73779048 Neighboring gene telomerase reverse transcriptase Neighboring gene STARR-seq mESC enhancer starr_34995 Neighboring gene STARR-seq mESC enhancer starr_34996 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 18 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand Neighboring gene solute carrier family 12, member 7 Neighboring gene STARR-seq mESC enhancer starr_34997 Neighboring gene STARR-seq mESC enhancer starr_35002 Neighboring gene naked cuticle 2 Neighboring gene predicted pseudogene 8062

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice. Cuny H, et al. Dis Model Mech, 2023 May 1. PMID 36374036, Free PMC Article
  2. Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. Bröer A, et al. J Biol Chem, 2011 Jul 29. PMID 21636576, Free PMC Article
  3. Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption. Javed K, et al. Nutrients, 2019 Aug 29. PMID 31470570, Free PMC Article
  4. Steady-state kinetic characterization of the mouse B(0)AT1 sodium-dependent neutral amino acid transporter. Camargo SM, et al. Pflugers Arch, 2005 Nov. PMID 16133263
  5. Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control. Jiang Y, et al. Mol Metab, 2015 May. PMID 25973388, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stage-Specific L-Proline Uptake by Amino Acid Transporter Slc6a19/B[0]AT1 Is Required for Optimal Preimplantation Embryo Development in Mice.
    Title: Stage-Specific L-Proline Uptake by Amino Acid Transporter Slc6a19/B(0)AT1 Is Required for Optimal Preimplantation Embryo Development in Mice.
  2. Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice.
    Title: Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice.
  3. Absorption of essential amino acids is reduced significantly in the absence of SLC6A19, especially following a high-protein diet.
    Title: Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption.
  4. analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin
    Title: Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
  5. Slc6a19 expression in the intestine is regulated at three different levels involving promoter methylation, histone modification, and opposing transcription factors.
    Title: Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks.
  6. the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 and the neutral amino acid transporter B0AT1
    Title: Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.
  7. Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse.
    Title: Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse.
  8. Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts.
    Title: Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response.
  9. Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo.
    Title: The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.
  10. functional association of mutant B(0)AT1 transporters with ACE2 and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder
    Title: Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Spontaneous (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC130422, MGC130423, 4632401C08Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutral amino acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sodium-dependent neutral amino acid transporter B(0)AT1
Names
solute carrier family 6 member 19
system B(0) neutral amino acid transporter AT1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359603.1 → NP_001346532.1  sodium-dependent neutral amino acid transporter B(0)AT1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and has an alternate start codon, and therefore differs in the 5' UTR compared to variant 1. These differences result in an isoform (2) with a novel N-terminus, compared to isoform 1.
    Source sequence(s)
    AC158359, AK162399, BP760806
    UniProtKB/TrEMBL
    Q3TRY2
    Related
    ENSMUST00000120322.8
    Conserved Domains (1) summary
    cl00456
    Location:21 → 517
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_028878.4 → NP_083154.1  sodium-dependent neutral amino acid transporter B(0)AT1 isoform 1

    See identical proteins and their annotated locations for NP_083154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158359, AK014544, AK028784, AK162399, BP760806, BY148246
    Consensus CDS
    CCDS26634.1
    UniProtKB/Swiss-Prot
    Q9D687
    UniProtKB/TrEMBL
    Q3KN89
    Related
    ENSMUSP00000022048.6, ENSMUST00000022048.6
    Conserved Domains (1) summary
    cl00456
    Location:32 → 612
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73827864..73848899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D687.1 GenPept UniProtKB/Swiss-Prot:Q9D687

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous