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4931414P19Rik RIKEN cDNA 4931414P19 gene [ Mus musculus (house mouse) ]

Gene ID: 74359, updated on 2-Nov-2024

Summary

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Official Symbol
4931414P19Rikprovided by MGI
Official Full Name
RIKEN cDNA 4931414P19 geneprovided by MGI
Primary source
MGI:MGI:1921609
See related
Ensembl:ENSMUSG00000022179 AllianceGenome:MGI:1921609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rtfc
Summary
Acts upstream of or within cell differentiation and positive regulation of gene expression. Predicted to be located in extracellular region. Orthologous to human C14orf93 (chromosome 14 open reading frame 93). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.6), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See 4931414P19Rik in Genome Data Viewer
Location:
14 C2; 14 27.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54821119..54843450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54583662..54606099, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36740 Neighboring gene ajuba LIM protein Neighboring gene STARR-seq mESC enhancer starr_36741 Neighboring gene STARR-positive B cell enhancer ABC_E7313 Neighboring gene U6 small nuclear RNA, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_36743 Neighboring gene STARR-positive B cell enhancer ABC_E7314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55236824-55237125 Neighboring gene proteasome (prosome, macropain) subunit, beta type 5 Neighboring gene microRNA 686 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 4931414P19Rik, a microglia chemoattractant secreted by neural progenitors, modulates neuronal migration during corticogenesis. Mestres I, et al. Development, 2023 May 1. PMID 37070770, Free PMC Article
  2. Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. Yu Y, et al. Sci Rep, 2017 Feb 23. PMID 28230092, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rtfc (4931414P19Rik) regulates in vitro thyroid differentiation and in vivo thyroid function.
    Title: Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein C14orf93 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028890.2 → NP_083166.1  uncharacterized protein C14orf93 homolog precursor

    See identical proteins and their annotated locations for NP_083166.1

    Status: PROVISIONAL

    Source sequence(s)
    CT009512
    Consensus CDS
    CCDS27094.1
    UniProtKB/Swiss-Prot
    Q8K2W9
    Related
    ENSMUSP00000022786.5, ENSMUST00000022786.6
    Conserved Domains (1) summary
    pfam15394
    Location:2 → 538
    DUF4616; Domain of unknown function (DUF4616)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54821119..54843450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158880.1 → XP_036014773.1  uncharacterized protein C14orf93 homolog isoform X2

    Conserved Domains (1) summary
    pfam15394
    Location:2 → 432
    DUF4616; Domain of unknown function (DUF4616)

  2. XM_006519618.5 → XP_006519681.1  uncharacterized protein C14orf93 homolog isoform X1

    See identical proteins and their annotated locations for XP_006519681.1

    UniProtKB/Swiss-Prot
    Q8K2W9
    Conserved Domains (1) summary
    pfam15394
    Location:2 → 538
    DUF4616; Domain of unknown function (DUF4616)

  3. XM_036158879.1 → XP_036014772.1  uncharacterized protein C14orf93 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8K2W9
    Conserved Domains (1) summary
    pfam15394
    Location:2 → 538
    DUF4616; Domain of unknown function (DUF4616)

  4. XM_011245210.4 → XP_011243512.1  uncharacterized protein C14orf93 homolog isoform X1

    See identical proteins and their annotated locations for XP_011243512.1

    UniProtKB/Swiss-Prot
    Q8K2W9
    Conserved Domains (1) summary
    pfam15394
    Location:2 → 538
    DUF4616; Domain of unknown function (DUF4616)

  5. XM_006519620.5 → XP_006519683.1  uncharacterized protein C14orf93 homolog isoform X1

    See identical proteins and their annotated locations for XP_006519683.1

    UniProtKB/Swiss-Prot
    Q8K2W9
    Conserved Domains (1) summary
    pfam15394
    Location:2 → 538
    DUF4616; Domain of unknown function (DUF4616)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2W9.1 GenPept UniProtKB/Swiss-Prot:Q8K2W9

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