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Duxf3 double homeobox family member 3 [ Mus musculus (house mouse) ]

Gene ID: 74399, updated on 2-Nov-2024

Summary

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Official Symbol
Duxf3provided by MGI
Official Full Name
double homeobox family member 3provided by MGI
Primary source
MGI:MGI:1921649
See related
Ensembl:ENSMUSG00000075046 AllianceGenome:MGI:1921649
Gene type
protein coding
RefSeq status
MODEL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933403O03Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Duxf3 in Genome Data Viewer
Location:
10 B4; 10 29.29 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58064887..58070140, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58229505..58233089, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene double homeobox protein 4-like protein 2 Neighboring gene double homeobox family member 2 Neighboring gene double homeobox family member 4 Neighboring gene double homeobox family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos. Xu R, et al. Cell Stem Cell, 2022 Jul 7. PMID 35803226
  2. Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Yang G, et al. Cell Stem Cell, 2021 Jan 7. PMID 33049217
  3. Precise temporal regulation of Dux is important for embryo development. Guo M, et al. Cell Res, 2019 Nov. PMID 31591446, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
double homeobox protein 4-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    58064887..58070140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245412.2 → XP_030101272.1  double homeobox protein 4-like protein 2

    UniProtKB/TrEMBL
    A0A0N4SV92, A1JVI6, A1JVI7
    Related
    ENSMUSP00000145004.2, ENSMUST00000176875.4
    Conserved Domains (2) summary
    smart00389
    Location:112 → 162
    HOX; Homeodomain
    cd00086
    Location:19 → 73
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033485.1: Suppressed sequence

    Description
    NR_033485.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials