Terb2 telomere repeat binding bouquet formation protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Terb2provided by MGI
Official Full Name: telomere repeat binding bouquet formation protein 2provided by MGI
Primary source: MGI:MGI:1921651
See related: Ensembl:ENSMUSG00000027229 AllianceGenome:MGI:1921651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933406J08Rik
Summary: Involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Acts upstream of or within meiosis I; oogenesis; and spermatogenesis. Located in chromosome, telomeric region and nuclear inner membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 59. Orthologous to human TERB2 (telomere repeat binding bouquet formation protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.56 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (122016753..122036874)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (122186272..122206393)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.
Title: The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.
The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
Title: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Study identified meiosis-specific telomere and inner nuclear membrane-binding proteins, telomere repeat-binding bouquet formation protein 2 (TERB2) and membrane-anchored junction protein (MAJIN), which form a complex with TERB1.
Title: MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic attachment of telomere to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic attachment of telomere to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic telomere clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: telomere repeats-binding bouquet formation protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.