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Batf2 basic leucine zipper transcription factor, ATF-like 2 [ Mus musculus (house mouse) ]

Gene ID: 74481, updated on 2-Nov-2024

Summary

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Official Symbol
Batf2provided by MGI
Official Full Name
basic leucine zipper transcription factor, ATF-like 2provided by MGI
Primary source
MGI:MGI:1921731
See related
Ensembl:ENSMUSG00000039699 AllianceGenome:MGI:1921731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-ATF-2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to protozoan and myeloid dendritic cell differentiation. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; central nervous system; dorsal root ganglion; lung; and spinal cord. Orthologous to human BATF2 (basic leucine zipper ATF-like transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 36.2), duodenum adult (RPKM 28.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Batf2 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6214424..6222506)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6164397..6172476)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6141140-6141385 Neighboring gene ADP-ribosylation factor-like 2 Neighboring gene predicted pseudogene 5510 Neighboring gene membrane anchored junction protein Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene glycoprotein hormone alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of BATF2 deficiency in immune microenvironment rearrangement in cervical cancer - New biomarker benefiting from combination of radiotherapy and immunotherapy. Zong Y, et al. Int Immunopharmacol, 2024 Jan 5. PMID 37995570
  2. BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection. van der Geest R, et al. Am J Physiol Lung Cell Mol Physiol, 2023 Nov 1. PMID 37724373, Free PMC Article
  3. BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection. Le DT, et al. iScience, 2023 Feb 17. PMID 36824275, Free PMC Article
  4. Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases. Guler R, et al. Mucosal Immunol, 2019 Mar. PMID 30542107, Free PMC Article
  5. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Kanemaru H, et al. Proc Natl Acad Sci U S A, 2017 Aug 29. PMID 28808017, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.
    Title: BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.
  2. BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
    Title: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
  3. SARI suppresses colitis-associated cancer development by maintaining MCP-1-mediated tumour-associated macrophage recruitment.
    Title: SARI suppresses colitis-associated cancer development by maintaining MCP-1-mediated tumour-associated macrophage recruitment.
  4. SARI prevents ocular angiogenesis and inflammation in mice.
    Title: SARI prevents ocular angiogenesis and inflammation in mice.
  5. SARI attenuated colitis in mice by impairing colitis-dependent STAT1/CCL2 transcriptional activation in IECs and macrophages recruitment in colon tissue.
    Title: SARI attenuates colon inflammation by promoting STAT1 degradation in intestinal epithelial cells.
  6. this study shows that BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway
    Title: BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway.
  7. BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation
    Title: BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation.
  8. these data reveal a regulatory role of Batf2 on the host immune responses to Type 1 (tuberculosis and listeriosis) and Type 2 (schistosomiasis) diseases
    Title: Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.
  9. Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation
    Title: Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation.
  10. controls Th17-mediated immunopathology by suppressing IL-23 production during Trypanosoma cruzi infection
    Title: BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • 4933430F08Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
basic leucine zipper transcriptional factor ATF-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356604.1 → NP_001343533.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC131114
    Consensus CDS
    CCDS89321.1
    Related
    ENSMUSP00000158113.2, ENSMUST00000237511.2
    Conserved Domains (2) summary
    cd14686
    Location:28 → 71
    bZIP; coiled coil [structural motif]
    cl21462
    Location:28 → 73
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. NM_001379529.1 → NP_001366458.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131114
    Conserved Domains (1) summary
    cd14701
    Location:25 → 71
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

  3. NM_028967.2 → NP_083243.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 1

    See identical proteins and their annotated locations for NP_083243.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC131114, CJ134251
    Consensus CDS
    CCDS29497.1
    UniProtKB/Swiss-Prot
    Q3TAI2, Q8R1H8
    Related
    ENSMUSP00000045744.8, ENSMUST00000045042.8
    Conserved Domains (1) summary
    cd14701
    Location:28 → 74
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6214424..6222506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318301.3 → XP_017173790.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X1

    Conserved Domains (1) summary
    cd14701
    Location:25 → 71
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1H8.1 GenPept UniProtKB/Swiss-Prot:Q8R1H8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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