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Mamstr MEF2 activating motif and SAP domain containing transcriptional regulator [ Mus musculus (house mouse) ]

Gene ID: 74490, updated on 2-Nov-2024

Summary

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Official Symbol
Mamstrprovided by MGI
Official Full Name
MEF2 activating motif and SAP domain containing transcriptional regulatorprovided by MGI
Primary source
MGI:MGI:1921740
See related
Ensembl:ENSMUSG00000042918 AllianceGenome:MGI:1921740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mastr; 2810022D01Rik; 5430432N15Rik
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within positive regulation of myotube differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human MAMSTR (MEF2 activating motif and SAP domain containing transcriptional regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 3.5), mammary gland adult (RPKM 1.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Mamstr in Genome Data Viewer
Location:
7 B3; 7 29.4 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45288616..45297631)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45639192..45648207)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 1 Neighboring gene izumo sperm-egg fusion 1 Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene netrin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression. Meadows SM, et al. Proc Natl Acad Sci U S A, 2008 Feb 5. PMID 18230740, Free PMC Article
  2. Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD. Yanay N, et al. Hum Mol Genet, 2019 Oct 15. PMID 31348492
  3. MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. Mokalled MH, et al. Genes Dev, 2012 Jan 15. PMID 22279050, Free PMC Article
  4. Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Creemers EE, et al. Mol Cell, 2006 Jul 7. PMID 16818234
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD
    Title: Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of myotube differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MEF2-activating motif and SAP domain-containing transcriptional regulator
Names
MEF2-activating SAP transcriptional regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172418.2 → NP_766006.2  MEF2-activating motif and SAP domain-containing transcriptional regulator

    See identical proteins and their annotated locations for NP_766006.2

    Status: VALIDATED

    Source sequence(s)
    AC149057, BY137380, BY145171, BY717195
    Consensus CDS
    CCDS21257.2
    UniProtKB/Swiss-Prot
    A1L0X1, E9QM68, Q0ZCJ7, Q3B818
    Related
    ENSMUSP00000114686.2, ENSMUST00000148532.4
    Conserved Domains (1) summary
    pfam02037
    Location:168 → 194
    SAP; SAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45288616..45297631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541232.3 → XP_006541295.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X1

    See identical proteins and their annotated locations for XP_006541295.1

    Conserved Domains (1) summary
    pfam02037
    Location:168 → 194
    SAP; SAP domain

  2. XM_006541234.3 → XP_006541297.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X2

    See identical proteins and their annotated locations for XP_006541297.1

    UniProtKB/Swiss-Prot
    A1L0X1, E9QM68, Q0ZCJ7, Q3B818
    Conserved Domains (1) summary
    pfam02037
    Location:168 → 194
    SAP; SAP domain

  3. XM_006541233.3 → XP_006541296.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X1

    See identical proteins and their annotated locations for XP_006541296.1

    Conserved Domains (1) summary
    pfam02037
    Location:168 → 194
    SAP; SAP domain

  4. XM_006541235.2 → XP_006541298.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X3

    Conserved Domains (1) summary
    pfam02037
    Location:66 → 92
    SAP; SAP domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146704.1: Suppressed sequence

    Description
    NM_001146704.1: This RefSeq was permanently suppressed because the CDS was partial, and the transcript retains intronic sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0ZCJ7.2 GenPept UniProtKB/Swiss-Prot:Q0ZCJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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